-
Recent Posts
- Meta-analysis of GWAS of gestational duration, and spontaneous preterm birth, identifies new maternal risk loci
- The crusade against carbon dioxide and integrity in climate science
- Pioneers of mRNA COVID vaccines win the 2023 Medicine Nobel
- Tasmanian tiger RNA is first to be recovered from an extinct animal
- How to train your jellyfish: brainless box jellies learn from experience
Recent Comments
Archives
- October 2023
- September 2023
- August 2023
- July 2023
- June 2023
- May 2023
- April 2023
- March 2023
- February 2023
- December 2022
- November 2022
- October 2022
- September 2022
- August 2022
- July 2022
- June 2022
- May 2022
- April 2022
- March 2022
- February 2022
- November 2021
- October 2021
- September 2021
- August 2021
- July 2021
- June 2021
- May 2021
- March 2021
- February 2021
- January 2021
- December 2020
- November 2020
- October 2020
- September 2020
- August 2020
- July 2020
- June 2020
- May 2020
- April 2020
- March 2020
- February 2020
- January 2020
- December 2019
- November 2019
- October 2019
- September 2019
- August 2019
- July 2019
- June 2019
- May 2019
- April 2019
- March 2019
- February 2019
- January 2019
- December 2018
- November 2018
- October 2018
- September 2018
- August 2018
- July 2018
- June 2018
- May 2018
- April 2018
- March 2018
- February 2018
- January 2018
- December 2017
- November 2017
- October 2017
- September 2017
- August 2017
- July 2017
- June 2017
- May 2017
- April 2017
- March 2017
- February 2017
- January 2017
- December 2016
- November 2016
- October 2016
- September 2016
- August 2016
- July 2016
- June 2016
- May 2016
- April 2016
- March 2016
- February 2016
- January 2016
- September 2006
- September 1995
- August 1995
- January 1995
- September 1994
- March 1994
- January 1994
Categories
Meta
-
Recent Posts
- Meta-analysis of GWAS of gestational duration, and spontaneous preterm birth, identifies new maternal risk loci
- The crusade against carbon dioxide and integrity in climate science
- Pioneers of mRNA COVID vaccines win the 2023 Medicine Nobel
- Tasmanian tiger RNA is first to be recovered from an extinct animal
- How to train your jellyfish: brainless box jellies learn from experience
Recent Comments
Archives
- October 2023
- September 2023
- August 2023
- July 2023
- June 2023
- May 2023
- April 2023
- March 2023
- February 2023
- December 2022
- November 2022
- October 2022
- September 2022
- August 2022
- July 2022
- June 2022
- May 2022
- April 2022
- March 2022
- February 2022
- November 2021
- October 2021
- September 2021
- August 2021
- July 2021
- June 2021
- May 2021
- March 2021
- February 2021
- January 2021
- December 2020
- November 2020
- October 2020
- September 2020
- August 2020
- July 2020
- June 2020
- May 2020
- April 2020
- March 2020
- February 2020
- January 2020
- December 2019
- November 2019
- October 2019
- September 2019
- August 2019
- July 2019
- June 2019
- May 2019
- April 2019
- March 2019
- February 2019
- January 2019
- December 2018
- November 2018
- October 2018
- September 2018
- August 2018
- July 2018
- June 2018
- May 2018
- April 2018
- March 2018
- February 2018
- January 2018
- December 2017
- November 2017
- October 2017
- September 2017
- August 2017
- July 2017
- June 2017
- May 2017
- April 2017
- March 2017
- February 2017
- January 2017
- December 2016
- November 2016
- October 2016
- September 2016
- August 2016
- July 2016
- June 2016
- May 2016
- April 2016
- March 2016
- February 2016
- January 2016
- September 2006
- September 1995
- August 1995
- January 1995
- September 1994
- March 1994
- January 1994
Categories
Meta
Category Archives: Pharmacogenetics
Another form of fraud and corruption in science: This time it has to do with fake data in drug trials
We’ve shared articles on “predatory online open-access” journals (at least 15,000 of them having popped up in the past 6-8 years) and recently fake research reagents being sold to scientists. Here [see attached article] is yet another form of fraud … Continue reading
Posted in Pharmacogenetics, Scientific breakthroughs
Comments Off on Another form of fraud and corruption in science: This time it has to do with fake data in drug trials
Double edged sword of DDT
This (Feb 2o17) article is a worthwhile read and relevant to Gene-Environment Interactions. “Too much of a good thing –– is not necessariily a good thing.” The Double-Edged Sword of DDT On Jan. 24, 2017, PBS aired a two-hour special … Continue reading
Posted in Center for Environmental Genetics, Gene environment interactions, Pharmacogenetics
Comments Off on Double edged sword of DDT
Do antibiotics have a larger therapeutic window than other drugs? A simple lesson in pharmacoloogy
A recent email chain has led to this GEITP topic worth sharing, a lesson in “Genetic Differences in Drug Response.” My original comment was that, “It would seem that all drugs exhibit interindividual differences in genetic response.” The (slight) challenge … Continue reading
Posted in Pharmacogenetics
Comments Off on Do antibiotics have a larger therapeutic window than other drugs? A simple lesson in pharmacoloogy
Marijuana usage appears to weaken heart muscle Nebert, Daniel (nebertdw)
This was reported yesterday on CNN News. Immediate thoughts that any scientist should consider include: ––– How important are genetic differences in THC response, between people? ––– Epidemiologically, this is a retrospective study, having various caveats. ––– “One swallow does … Continue reading
Posted in Center for Environmental Genetics, Gene environment interactions, Pharmacogenetics, Toxicology
Comments Off on Marijuana usage appears to weaken heart muscle Nebert, Daniel (nebertdw)
Genetic differences in addiction to morphine … in ants, no less …!!!
Here is a GREAT example of “evolutionary conservation” of genetic pathways in the central nervous system (CNS) between the Order Hymenoptera (including ants) and Primata (primates, including humans). Ants are eusocial insects of the family Formicidae and––along with the related wasps and bees––belong to the order Hymenoptera. Ants evolved from wasp-like ancestors … Continue reading
Posted in Center for Environmental Genetics, Pharmacogenetics
Comments Off on Genetic differences in addiction to morphine … in ants, no less …!!!
Evidence that 5p12 variant rs10941679 confers susceptibility to estrogen-receptor-positive breast cancer through FGF10 and MRPS30 regulation
Etiology (underlying causes) of breast cancer remain among the biggest mysteries in current cancer research. And, after this publication, breast cancer etiology remains as big a mystery as before. Genome-wide association studies (GWAS) have revealed increased breast cancer risk associated … Continue reading
Posted in Gene environment interactions, Pharmacogenetics
Comments Off on Evidence that 5p12 variant rs10941679 confers susceptibility to estrogen-receptor-positive breast cancer through FGF10 and MRPS30 regulation
“New and improved” method, Relative Citation Ratio (RCR) ..??
Despite all the recognized limitations, bibliometric assessments of scientific productivity have become increasingly widely adopted. Authors [below] describe herein what they believe is “an improved method to quantify the influence of a research article”. They propose to make use of … Continue reading
Posted in Center for Environmental Genetics, Pharmacogenetics
Comments Off on “New and improved” method, Relative Citation Ratio (RCR) ..??
Discovery of a eukaryote not having mitochondria !!!
Every living organism is categorized as either a prokaryote (having single chromosomes) or eukaryote (having pairs of chromosomes). Eukaryotes also contain a nucleus surrounded by a membrane, and its DNA is bound together by proteins (histones) into chromosomes. Eukaryotic cells are … Continue reading
Posted in Pharmacogenetics
Comments Off on Discovery of a eukaryote not having mitochondria !!!
“Polypharmacy” is the clinical term for drug-drug interactions (DDIs) in clinical pharmacy
This article appeared in a recent issue of the New York Times. Each drug can be considered as “an environmental chemical”, with regard to studying one drug’s effect on a patient, or the patient’s response to that one drug. REPOSTED … Continue reading
Posted in Pharmacogenetics
Comments Off on “Polypharmacy” is the clinical term for drug-drug interactions (DDIs) in clinical pharmacy
Having “disease mutational variants” (genotype) but not exhibiting the disease (phenotype)
This is a very interesting exciting study, a great example of “thinking outside the box”. Genetic studies of human Mendelian diseases (one or few mutations in one or few genes) have traditionally focused on detection of the disease-causing mutations in … Continue reading
Posted in Center for Environmental Genetics, Pharmacogenetics
Comments Off on Having “disease mutational variants” (genotype) but not exhibiting the disease (phenotype)