Author Archives: DWN

MORE FRAUD: Hundreds of cancer papers mention cell lines that don’t seem to exist (!!!)

Just when you think that “any further audacious FRAUD (in publishing scientific papers) cannot be possible” (because all possible forms of corruption have already been invented) — along comes something new and even more dishonest. ☹ Research integrity investigators (16 … Continue reading

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The amazing phenomenon of de novo gene birth — how does a new gene evolve?

In these GEITP email blogs, we have often discussed genes that are a member of this or that “gene family,” and we know that members of a gene family generally arise from the original ancestral gene. But, going back further … Continue reading

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When Rebellion Becomes Virtue: How the Scientific Method Came to Be

This is for your evening bedtime reading enjoyment. The long essay below—and some further contributions from various colleagues—are the result of someone initially asking the question: WHEN was the Scientific Method first established? and WHO should be credited with establishing … Continue reading

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Photoreceptor Evolution–from Water Animals to Land Animals

This topic is among the most clear-cut examples of “gene-environment interactions” topics…!! During evolution, when vertebrates first left the water and ventured onto land, they encountered a visual world that was radically different from that of their aquatic ancestors. In … Continue reading

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Epigenome-wide association study of total nicotine equivalents

For gene-environment interactions, the environmental “signal” in this story represents the urinary “total nicotine equivalents”, a quantitative assay for cigarettes actually smoked (which is more reliable than the patient’s estimate of their smoking history). The genetic “response” in this story … Continue reading

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Transcriptome-wide association study (TWAS) of the plasma proteome

s described many times in these GEITP email blogs — to discover a gene or genetic loci that is/are correlated with a simple or complex trait (phenotype) of your choosing, genome-wide association studies (GWASs) have been commonly used as a … Continue reading

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Found: the dial in the brain that controls the immune system (??)

This is a layman’s description of a very recent paper published in Nature. And, as these articles usually do, they don’t provide enough scientific details for scientists to judge for themselves… But this brief overview always sounds very exciting, like … Continue reading

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The LNT Model

[I always open “CC” (closed captions), if it’s available, to help me understand what speakers are saying.] To refresh everyone’s memory about the “LNT Model,” recall that GEITP has discussed this topic at least a half-dozen times. Ed Calabrese, emeritus … Continue reading

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Genome evolution and divergence in cis-regulatory architecture is associated with condition-responsive development in horned dung beetles

This topic is “a first for GEITP” (!!) : studying developmental evolution in the dung beetle. In our 16 years of existence, GEITP is certain that we’ve never discussed gene regulation in the dung beetle before…!! ☹ This is a … Continue reading

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The NIH Sacrifices Scientific Rigor for DEI

Pasted below is an excellent brief article/letter — on a topic that is mostly forbidden to discuss (i.e., that the government “is sacrificing its highest standards of scientific creativity” in order to fully embrace DEI). I’ve had experiences and have … Continue reading

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