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Monthly Archives: September 2020
A Commericial Sunscreen Modulates Aryl Hydrocarbon Receptor-Signaling in Keratinocytes and Inhibits CYP1A1 and CYP1B1 Enzyme Activities
This topic involves gene-environment interactions. Octinoxate (a sunscreen) is the “environmental signal”, and genetic activation via aryl hydrocarbon receptor (AHR)-signaling represents the “response to the signal.” We are constantly exposed to varying levels of ultraviolet radiation (UVR) from the sun … Continue reading
Posted in Center for Environmental Genetics
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Changes in regeneration-responsive enhancers affect regenerative capacities in vertebrates
This topic is within the theme of gene-environment interactions. The “environmental signal” is — loss of a body part. ☹ The “response to that signal” is — let’s mobilize our transcription factors and regulatory elements and activate our genetic networks … Continue reading
Posted in Center for Environmental Genetics
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Regulation of sleep homeostasis mediator (adenosine) in the mouse — mostly by glutamatergic neurons
At first glance, this topic might not seem to be related to the GEITP theme of gene-environment interactions. However, the “environmental signal” (in this case, an endogenous compound from cells other than the target neurons) is a “somnogenic factor” and … Continue reading
Posted in Center for Environmental Genetics
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The pandemic—from the virus’ point-of-view
This timely article (surprisingly, from The New York Times) fits very nicely with GEITP’s gene-environment interactions theme. The author writes very clearly and eloquently, with elegant similes. And his approach (in this article) is the same way that we should … Continue reading
Posted in Center for Environmental Genetics
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Antihistamines May Help Calm COVID-19 Cytokine Storm
This study might be of interest to some GEITP’ers. Perhaps the most significant news in this study — is that both drugs are already FDA-approved, over-the-counter (OTC), and easy to acquire. 😊 DwN Antihistamines May Help Calm COVID-19 Cytokine Storm … Continue reading
Posted in Center for Environmental Genetics
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Prion-like domain in ELF3 acts as a thermosensor in the plant Arabidopsis
Today we have a “natural” as a topic for gene-environment interactions. And “prions” are mentioned again — just after an article about prions 2-3 days ago in these GEITP pages. Today the “environmental signal” is temperature (heat vs cold), and … Continue reading
Posted in Center for Environmental Genetics
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Accumulation of storage proteins in plant seeds is mediated by amyloid formation
Just as “prions” were first discovered in humans — and now are realized to exist in not only all animals but also yeast, fungi and plants — and carry out important functions — so we learn [from the attached article] … Continue reading
Posted in Center for Environmental Genetics
Comments Off on Accumulation of storage proteins in plant seeds is mediated by amyloid formation
Mouse NRF2 loss recapitulates heritable impacts of paternal cigarette smoke exposure in next-generation offspring
As these GEITP pages have often stated, any trait (phenotype) reflects contributions of: genetics (differences in DNA sequence); epigenetic factors (chromosomal events independent of DNA sequence: DNA methylation, RNA interference, histone modifications, and chromatin remodeling); environmental effects (smoking, diet, lifestyle); … Continue reading
Posted in Center for Environmental Genetics
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Origin and the elaboration of a major evolutionary transition in individuality
This topic fits nicely the theme of gene-environment interactions — the “environmental signal” is the life cycle of Camponotini (ant tribe containing two extinct genera and eight extant genera — including the carpenter ant); the “response to the signal” is … Continue reading
Posted in Center for Environmental Genetics
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Spontaneous generation of prions and transmissible PrP amyloid in a humanized transgenic mouse model of A117V Gerstmann-Sträussler-Scheinker (GSS)
“Consensus science” is the risky situation whereby “a majority of ‘scientists’ might agree upon a ‘fact’ they fervently believe to be true.” The consensus may or may not turn out to be confirmed by further research, but we should remember … Continue reading
Posted in Center for Environmental Genetics
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