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- HGNC NewsLetter, Summer 2023
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Monthly Archives: June 2020
Did lockdowns really save 3 million COVID-19 deaths, as Flaxman et al. claim?
Did lockdowns really save 3 million COVID-19 deaths, as Flaxman et al. claim? Posted on June 21, 2020 By Nic Lewis Key points about the recent Nature paper by Flaxman and other Imperial College modellers 1) The transition from rising … Continue reading
Posted in Center for Environmental Genetics
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Statistical Analysis of the Extensive Bioassay Data on Glyphosate
Glyphosate is a famous phosphonomethyl amino acid herbicide used extensively throughout the world in weed control; its fame lies in the quantity of hysterical claims about how carcinogenic it is vs alternative claims that it does not cause cancer. The … Continue reading
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Low-Dose Radiation Therapy May Help COVID-19 Patients ???
This article just came out on MedScape. Ed Calabrese has been talking about this lately. This article should make him happy. 😊 Hormesis is defined as “any process in a cell or organism that exhibits a biphasic response to exposure, … Continue reading
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Over a century of cancer research: “inconvenient truths” and promising leads
Despite more than a century of intensive research, including the “great gains” promised by the “War on Cancer” (in 1971), our understanding of the fundamental etiology of this complex disease is still incomplete. Authors [see attached essay] analyze the “lack … Continue reading
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A unified nomenclature for vertebrate olfactory receptors
Olfactory receptors (ORs) are G-protein-coupled receptors which are used for odor detection. Being the largest gene family in vertebrates, a typical mammalian genome harbors ~1000 OR genes and pseudogenes. However, the numbers of functional OR genes vary enormously among genomes … Continue reading
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Are Patients Dying ‘from’ COVID or ‘with’ COVID?
Are Patients Dying ‘from’ COVID or ‘with’ COVID? George D. Lundberg, MD June 05, 2020 Death is usually fairly easy to diagnose; cause of death, not so much. In fact, death certificates in the United States and around the world … Continue reading
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Dendritic cell-derived hepcidin: the hormone that sequesters iron from the microbiome to promote mucosal healing
As these GEITP pages often discuss, every trait (phenotype) represents the contribution of genetics (DNA sequence) epigenetic factors (DNA methylation, RNA interference, histone modifications, chromatin remodeling), environmental effects (diet, lifestyle, smoking), endogenous influences (cardiopulmonary disease, renal status), and each person’s … Continue reading
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The gut-brain axis mediates sugar preference
Sugar is a fundamental source of energy for all animals and, correspondingly, most species have evolved dedicated brain circuits to seek, recognize and motivate consumption of sugar. In humans, recruitment of these circuits for reward and pleasure — rather than … Continue reading
Posted in Center for Environmental Genetics
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Accurate and Scalable Construction of Polygenic Risk Scores (PRS) in Large Biobank Data Sets; Predictive Utility of PRS for Coronary Heart Disease in 3 Racial and Ethnic Groups
As these GEITP pages have often discussed, there are relatively simple monogenic (Mendelian) traits — in which one or only a few genes contribute to the phenotype (trait) — and multifactorial traits (e.g. human complex diseases and quantitative traits such … Continue reading
Posted in Center for Environmental Genetics
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An epigenome-wide association study of posttraumatic stress disorder (PTSD) in US veterans implicates several new DNA methylation loci
This fascinating topic fits perfectly the theme of gene-environment interactions. The environmental “signal” is severe stress, and the response by the genome of some (but not all) individuals is to develop post-traumatic stress disorder (PTSD). In the early 1990s, “a … Continue reading
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