Monthly Archives: March 2019

Per- and polyfluoroalkyl substances (PFAS) in our environment are persistent chemicals — should we worry ???

For anyone interested, below [also attached as a pdf file] is a publication described by Phil Guzelian that PFOA at varying doses may benefit patients with terminal cancer, while having undesirable side-effects at other doses. As far as these PFASs, … Continue reading

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“Past five years are warmest on record” [declares this Nature journal news item]

“Past five years are warmest on record” (screams out the headline of this brief news paragraph in the Feb 14th 2o19 issue of Nature). The 1-paragraph article goes on to say: “The average global temperature for 2018 was ‘the fourth … Continue reading

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Using CRISPR/Cas9 to study and evoke “molecular drive” in insects

“Gene drive” or “Molecular drive” are different names for adaptation of an organism to any changing environment. This topic is obviously very central to gene-environment interactions. Mendel in the 19th century observed consistent patterns of inheritance that corresponded to each … Continue reading

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Does Climate Change Threaten National Security?

These GEITP pages have often included topics of fraud and corruption in science, as it relates to gene-environment interactions. As these pages have recently mentioned, there are strong political forces opposed to overturning the Linear No-Threshold (LNT) Model used in … Continue reading

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Mexico’s monarch butterfly more than doubles this winter — Why?

This Monarch Butterfly Annual Migration represents an intriguing example of gene-environment interactions. Each winter, Monarch butterflies — from Canada and the northeastern and midwestern United States — flock to the pine and fir forests of central Mexico to hibernate, covering … Continue reading

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The NEW TREND: genome-wide association studies (GWAS) with cohorts >1 million (or many millions of) individuals

These large multi-center consortia have the facilities to carry out such enormous GWAS, and the ability to collect all the necessary DNA (or more likely, to collect information from GWAS already completed, plus questionnaire data). Superficially, one might conclude that … Continue reading

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Genome-wide analysis of INSOMNIA in more than 1 million individuals !!!

I can’t say that I have heard of “Fatal Familial Insomnia.” So –– what I do in that case –– is go to the OMIM web site (Online Mendelian Inheritance in Man), created by my colleague and friend Victor McKusick. … Continue reading

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The NEW TREND: genome-wide association studies (GWAS) with cohorts >1 million (or many millions of) individuals

On 25 Feb 2019, these GEITP pages described “an unprecedented cohort size of more than 1 million”, in which a genome-wide association study (GWAS) was carried out to search for genes (genotype; or genetic architecture) statistically significantly (P

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“Origins of Life” have been created by a NASA experiment ???

As these GEITP pages have considered from time to time, how “life” began on Earth is relevant to gene-environment (GxE) interactions — in some ways similar to the relevance of GxE to evolution of life over the past 4+ billion … Continue reading

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Separating host and microbiome contributions to drug pharmacokinetics and drug toxicity

These GEITP pages have discussed, on several occasions, the importance of the “brain-gut-microbiome” (i.e. interaction of each patient’s gut bacteria/virus/fungus with intestine AND brain of the same patient). Of all the many ways the ecosystem of microbes (comprising 92% of … Continue reading

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