Monthly Archives: November 2018

The relative contribution of DNA-methylation and genetic variants on protein biomarkers for human diseases

Over the past decade, these GEITP pages have covered many genome-wide association studies (GWAS), because these projects are attempts to detect DNA sequence variants that are (statistically significantly) associated with complex diseases (e.g. type-2 diabetes, schizophrenia, obesity, cancer) or responses … Continue reading

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Solar Cycle Update (Nov 2o18): Is warmth sticking around, or cooling ahead?

THIS ANALYSIS represents the current cutting-edge of Climate Science. It would be impossible to READ and COMPREHEND all of this –– and then still insist that: [a] Human activity is causing “climate change”, [b] Earth today continues to “get warmer”, … Continue reading

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proposal to sequence all 1.5 million species on Earth during next 10 years !!!

The (mind-boggling) Earth BioGenome Project — a VERY AMBITIOUS $4.7 billion, 10-year plan to sequence the genomes of all of Earth’s 1.5 million known species of animal, plant, fungus, and protozoan — officially began the first week of November 2o18 … Continue reading

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536 A.D. Was a ‘Horrible Year for Mankind’

This fascinating article just appeared in LiveScience.com and I thought it was just too good not to share. If a volcanic eruption is sufficiently large –– followed by several more substantially large eruptions –– such geothermal events can affect weather … Continue reading

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The “exposome” PLUS visualization of a transcriptional complex on the enhancer/promoter region on a DNA segment on one chromosome in a single cell

The topic [far below] discusses the “exposome” and realization that current intrumentation might provide you with the result that a chemical is “undetectable at 10–14 or 10–17 molar“, which does not rule out that as many as ~6x 109 (6,000,000,000) … Continue reading

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COMMENT: Dear Dr. Nebert, I would say that this publication is an “important article.” It has been highlighted in many news reports and scientific conferences –– including last month’s Amercan Society of Human Genetics meeting in San Diego. I think … Continue reading

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Dynamic interplay visualized — between enhancer/promoter regions and gene activity

Transcriptional enhancers are short DNA fragments [5 base-pairs (bp) to 25-30 bp] that control gene expression; enhancers can be nearby “upstream” or “downstream”, inside the gene (in an intron that does not get transcribed into the final messenger RNA which … Continue reading

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Genome-wide polygenic scores for common diseases identify individuals with risk eequivalent to monogenic mutations

Genome-wide association studies (GWAS) began more than 12 years ago, with the hope that clinical geneticists would soon be able to [a] predict genetic risk of complex diseases, and [b] find new pathways for which new drugs might be developed … Continue reading

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The American Journal of Human Genetics: November 1, 2018 (Volume 103, Issue 5)

Although everything is a gradient, complex genetic diseases (e.g. obesity, type-2 diabetes, schizophrenia, and cancer) and quantitative traits (e.g. height, body mass index, and I.Q.) usually differ from monogenic traits and diseases (e.g. phenylketonuria, sickle-cell anemia, and tyrosinemia). Traits (phenotypes) … Continue reading

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Last universal common ancestor (LUCA) between ancient Earth chemistry and the onset of genetics

There was a time when there was no life on Earth (i.e. only the environment). And there was a time when there were DNA-inheriting cells (i.e. there were gene-environment interactions). Transitioning from the former to the latter is difficult to … Continue reading

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