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- Human ancestors passed through a very serious bottleneck
- HGNC NewsLetter, Summer 2023
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Monthly Archives: November 2017
Previous history of biology preprints: A forgotten experiment from the 1960s
This [attached] article is an intriguing bit of history about scientific “preprint” publications. Since 1991, physicists and mathematicians have been using the arXiv preprint repository to circulate articles and ideas, to the envy of many biologists. After a number of … Continue reading
Posted in Center for Environmental Genetics
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Oral statins appear to help the host in combating antibiotic-resistant bacteria
Cell integrity depends on the precise organization of its limiting cell membranes, whose molecular organization we understand poorly. The established dogma about the fluid mosaic model had suggested that membrane proteins and lipids diffuse freely and therefore are homogenously distributed. … Continue reading
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MORE: Dilemma: the rise of the predatory journal
Below is another horror story that Professor Eaton wishes to share with everyone. Because I receive 20-30 of these bogus emails each day, I could offer perhaps some insight to one or several “key words” that I see in virtually … Continue reading
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Dilemma: the rise of the predatory journal
These GEITP pages will continue to share horror stories related to these “online open-access predatory journals” that have exploded in number during the past decade. This one today should be especially of interest to dog lovers. Dog of a dilemma: … Continue reading
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Sequencing of ancient genomes from southern Africa — helps in estimating modern human divergence between 350K and 260K years ago
As discussed many times on these GEITP pages –– archaeological, fossil, and genetic data have positioned the early traces of anatomically modern humans in sub-Saharan Africa. The earliest (completely) modern human remains, dating to ~190,000 years ago, originate from Ethiopia. … Continue reading
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Reviewer bias in single- versus double-blind peer review
Peer review (colleagues, peers, reviewing a manuscript submitted for publication in some journal) can be “single-blind” (reviewers are aware of the names and affiliations of paper authors), or “double-blind” (this information is hidden from the Reviewer). Noticing that computer-science research … Continue reading
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CRISPR/Cas9 technology is already being superceded by more accurate (fewer downstream non-targets affected) single-DNA or -RNA editing
Ever since the start of the CRISPR craze 5 years ago, scientists have raced to invent ever-more-versatile, or efficient, variations of this powerful tool, which vastly simplifies the editing of DNA (e.g. instead of requiring 4-6 months to create a … Continue reading
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Large genome-wide association study(ies) identify 65 new breast cancer risk loci !!!
Breast cancer risk is a perfect example of a multifactorial trait –– which these GEITP pages have continued to scrutinize and underscore importance. I still recall discovery of the BRCA1 gene (1994) when it was declared “THE breast cancer risk … Continue reading
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How evolution of modern-day humans has influenced mental illness
As discussed often in these GEITP pages, psychiatric disorders represent multifactorial traits (i.e. phenotypes caused by the contribution of hundreds if not thousands of gene mutations, plus epigenetic effects, plus environmental adversities that can accumulate over decades of time). Other … Continue reading
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More findings of Neaderthal DNA contributions to modern human (Homo sapiens)
As these GEITP pages have often described, there is no simple diagram to illustrate migrations of modern humans (Homo sapiens) out of southeast Africa during the past 1-2 million years. Both Neanderthals (Homo neanderthalensis) and modern humans are likely to … Continue reading
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