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Furthermore, authors found that the cytosolic translation processes control mitochondrial translation uni-directionally––i.e. the nuclear genome coordinates mitochondrial, and cytosolic, translation to orchestrate the timely synthesis of OXPHOS complexes, representing an unappreciated regulatory layer that shapes the mitochondrial proteome. This interesting whole-cell genomic profiling approach (looking concomitantly at gDNA and mtDNA transcription) establishes a foundation for studies of global gene regulation in mitochondria.
Nature 26 May 2o16; 533: 499 – 503 and ‘News & Views” editorial, pp 472-473
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Furthermore, authors found that the cytosolic translation processes control mitochondrial translation uni-directionally––i.e. the nuclear genome coordinates mitochondrial, and cytosolic, translation to orchestrate the timely synthesis of OXPHOS complexes, representing an unappreciated regulatory layer that shapes the mitochondrial proteome. This interesting whole-cell genomic profiling approach (looking concomitantly at gDNA and mtDNA transcription) establishes a foundation for studies of global gene regulation in mitochondria.
Nature 26 May 2o16; 533: 499 – 503 and ‘News & Views” editorial, pp 472-473
