Category Archives: Center for Environmental Genetics

Selfish genetic elements (or “selfish DNA”)

Thanks, S…… I’ve ALWAYS been fascinated with the idea of the “genome as a community.” When scientists knock out one gene — in one cell-type (or globally) — this loss is somehow “sensed.” Then the genome “sets up a committee,” … Continue reading

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Distinguishing genetically between the germlines of male monozygotic twins

There are intriguing differences in the rate of human twinning worldwide — with less than eight per 1000 live births in Asia to greater than 18 per 1000 live births in Central Africa. Such geographic variations are mainly due to … Continue reading

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The Linear No-Threshold (LNT) dose response model: A comprehensive assessment of its historical and scientific foundations

An entire issue of Chemico-Biological Interactions (published 1 March 2019) is devoted to the topic of the Linear No-Threshold (LNT) Model. [Attached] is the contribution by Ed Calabrese, who says this “represents my most comprehensive assessment yet, of this topic.” … Continue reading

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Per- and polyfluoroalkyl substances (PFAS) in our environment are persistent chemicals — should we worry ???

For anyone interested, below [also attached as a pdf file] is a publication described by Phil Guzelian that PFOA at varying doses may benefit patients with terminal cancer, while having undesirable side-effects at other doses. As far as these PFASs, … Continue reading

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“Past five years are warmest on record” [declares this Nature journal news item]

“Past five years are warmest on record” (screams out the headline of this brief news paragraph in the Feb 14th 2o19 issue of Nature). The 1-paragraph article goes on to say: “The average global temperature for 2018 was ‘the fourth … Continue reading

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Using CRISPR/Cas9 to study and evoke “molecular drive” in insects

“Gene drive” or “Molecular drive” are different names for adaptation of an organism to any changing environment. This topic is obviously very central to gene-environment interactions. Mendel in the 19th century observed consistent patterns of inheritance that corresponded to each … Continue reading

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Does Climate Change Threaten National Security?

These GEITP pages have often included topics of fraud and corruption in science, as it relates to gene-environment interactions. As these pages have recently mentioned, there are strong political forces opposed to overturning the Linear No-Threshold (LNT) Model used in … Continue reading

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Mexico’s monarch butterfly more than doubles this winter — Why?

This Monarch Butterfly Annual Migration represents an intriguing example of gene-environment interactions. Each winter, Monarch butterflies — from Canada and the northeastern and midwestern United States — flock to the pine and fir forests of central Mexico to hibernate, covering … Continue reading

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The NEW TREND: genome-wide association studies (GWAS) with cohorts >1 million (or many millions of) individuals

These large multi-center consortia have the facilities to carry out such enormous GWAS, and the ability to collect all the necessary DNA (or more likely, to collect information from GWAS already completed, plus questionnaire data). Superficially, one might conclude that … Continue reading

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Genome-wide analysis of INSOMNIA in more than 1 million individuals !!!

I can’t say that I have heard of “Fatal Familial Insomnia.” So –– what I do in that case –– is go to the OMIM web site (Online Mendelian Inheritance in Man), created by my colleague and friend Victor McKusick. … Continue reading

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