Category Archives: Center for Environmental Genetics

Recessive gene disruptions in autism spectrum disorder

These GEITP pages have often chatted about autism spectrum disorder (ASD) — because it represents a mysterious complex disease that is clearly multifactorial (i.e. the trait represents contribution of genes, epigenetic effects, environmental factors, and perhaps endogenous influences and the … Continue reading

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High-throughput identification of human SNPs affecting regulatory element activity

Frequently these GEITP pages have chatted about gene expression, which is constantly being altered by environmental signals; these signals stimulate a cascade of downstream reactions which of course begin by tickling the regulatory elements that control gene expression, make the … Continue reading

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Advances in epigenetics link genetics to the environment and disease (Nice Review)

Biologists have long sought to understand how a fertilized egg can form an organism composed of hundreds of specialized cell-types, each expressing a defined set of genes. Same with an acorn: how does this little nut form an oak tree, … Continue reading

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HGNC Summer 2019 NewsLetter and DR Nelson Blog on “Seeing Red

Pasted below is the Summer 2019 NewsLetter for the HUGO Gene Nomenclature Committee (HGNC) — which has now combined forces with the Vertebrate Gene Nomenclature Committee (VGNC). Below that is their first blog, this one by that “famous gene superfamily … Continue reading

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Evidence that DNA repair genes, a family of tumor suppressor genes, are associated with evolution rate and size of genomes

Consistent with the theme of “evolution” that is often discussed in these GEITP pages, “adaptive radiation” is a well-known phenomenon in evolutionary biology — in which a taxon (a taxonomic group of any rank, such as a class, family, order, … Continue reading

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Studies on the occurrence of cytochrome P450 genes (CYPs) in viruses

Cytochromes P450 (CYPs) are important enzymes that undoubtedly appeared very early in evolution — because these genes are found today in archaebacteria, eubacteria, plants, fungi and animals — as well as in several dozen viruses. In mammals, these enzymes carry … Continue reading

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How do genes come about — in the first place ???

These GEITP pages have the over-reaching theme of gene-environment interactions. This includes evolution of life (archaebacteria, eubacteria, plants, fungi & animals) and, accordingly, evolution of genes (especially in response to environmental stress, i.e. climate, diet, need for food & reproduction … Continue reading

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High-throughput single-cell ChIP-seq identifies heterogeneity of chromatin states in breast cancer

As these GEITP pages have often discussed, in order to understand the contribution of genes and other factors to any selected phenotype (trait, such as schizophrenia, obesity, response to a drug, or response to an environmental toxicant) — assays have … Continue reading

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Whole-genome deep-learning analysis identifies contribution of noncoding mutations to autism risk

These GEITP pages maintain the theme of gene-environment (GxE) interactions. Autism spectrum disorder (ASD) has often been included as one of our topics, because this fascinating complex disease is a multifactorial trait — that might include not only GxE interactions, … Continue reading

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Genetic analyses of diverse populations improves discovery for complex traits

This article [attached] was described earlier — in these GEITP pages (on July 3rd) in layman’s terms [pasted again at the bottom of this email]. The Population Architecture using Genomics and Epidemiology (PAGE) study was developed by the National Human … Continue reading

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