Category Archives: Center for Environmental Genetics

Large genome-wide association study(ies) identify 65 new breast cancer risk loci !!!

Breast cancer risk is a perfect example of a multifactorial trait –– which these GEITP pages have continued to scrutinize and underscore importance. I still recall discovery of the BRCA1 gene (1994) when it was declared “THE breast cancer risk … Continue reading

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How evolution of modern-day humans has influenced mental illness

As discussed often in these GEITP pages, psychiatric disorders represent multifactorial traits (i.e. phenotypes caused by the contribution of hundreds if not thousands of gene mutations, plus epigenetic effects, plus environmental adversities that can accumulate over decades of time). Other … Continue reading

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More findings of Neaderthal DNA contributions to modern human (Homo sapiens)

As these GEITP pages have often described, there is no simple diagram to illustrate migrations of modern humans (Homo sapiens) out of southeast Africa during the past 1-2 million years. Both Neanderthals (Homo neanderthalensis) and modern humans are likely to … Continue reading

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Enhancer modules (affecting gene up- or down-regulation) are often not closest to the gene it regulates :(

The earliest genome-wide association studies (GWAS) immediately raised the question of what genes are the targets of the identified disease risk variants (single-nucleotide variants; SNVs), located sometimes inside a gene, but more often, located some distance upstream (or downstream) of … Continue reading

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Transplanting human cancers into mouse –> (surprise, surprise) genotype and phenotype tends to change rather quickly

Use of patient-derived models, in which part of a human tumor is transplanted into mice (also known as patient-derived xenografts, or PDXs), is gaining traction as a method to investigate tumor behavior such as “response to therapies”. Human-derived tumor models … Continue reading

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Analysis Commons, a team approach to discovery — in a big-data environment for genetic epideniology

The “Analysis Commons” –– which relies on a new team-science model for genetic epide­miology –– integrates multi-omic data and rich phenotypic and clinical information from diverse population studies into a single shared analytic platform that leverages the resources of a … Continue reading

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Manipulation of meteorological data by NOAA and NASA over the past 30-40 years – comments

First, I want to emphasize that there is a scientific field of climatology, which needs to be kept distinct from the political science field of non-scientific-based opinions and emotions. I believe that I can answer your email because (as you … Continue reading

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Register now: For the 2nd SRP webinar on Adverse Outcome Pathways (AOPs), November 29, 1 pm EST

For anyone interested, the NIEHS Superfund Research Program is inviting you to join them for the second session of the “Risk e-Learning” webinar series on Adverse Outcome Pathways (AOPs). For anyone who missed the first session (“Introduction to the Adverse … Continue reading

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The unrelenting search for historical truth

The attached fascinating article summarizes the Journey that Ed Calabrese has undertaken, for most of the past decade, leading to discovery of the discrepancies of the Linear No-Threshold (LNT) Model –– for which Hermann Müller was awarded the 1946 Nobel … Continue reading

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The dynamics of molecular evolution during 60,000 generations of the Escherichia coli (E. coli) bacterium

After the recent sharing of a GEITP report about a bird’s beak “evolving” to become longer –– to accommodate decades of birdfeeders in the gardens of England –– here is another example of “Evolution in Action.” The Escherichia coli long-term … Continue reading

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