Category Archives: Center for Environmental Genetics

One of the Most Widely Used Methods in Epigenetics Can Cause Misleading Results

This BREAKTHROUGH paper (reported today in FRONTLINE GENOMICS) is very important to those in the field (e.g. Sean Zhang), so I have moved it “to the front of the QUEUE.” There is nothing worse than spending a lot of time, … Continue reading

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Moving on into a New Frontier: “3-dimensional genomics” (the way the chromosomes are situated in the nucleus)

As these GEITP pages keep harping on –– the factors that contribute to any trait (response to a drug or environmental toxicant, hair color, height, blood pressure, risk of type-2 diabetes, risk of autism spectrum disorder, etc.) include: genotype (DNA … Continue reading

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New human gene (increased) tally reignites debate

This is a recent editorial in Nature. DwN New human gene (increased) tally reignites debate Some fifteen years after the human genome was sequenced, researchers still can’t agree on how many genes it contains ––––Cassandra Willyard One of the earliest … Continue reading

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How did Life begin?

his topic is a bit on the periphery of ‘Gene-Environment Interactions,’ but –– without Life on Earth –– we wouldn’t have genes to interact with the environment. 🙂 How and Why did Life come to exist on this planet? Is … Continue reading

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All Young Cannabis Users Face Higher Risk of Psychosis

The breakthrough/landmark study was published recently in J Am Med Assn Psychiatry, but this article on MedScape today is what caught my attention. Every one of us has had experience with family members, relatives, neighbors, and/or friends who have seen … Continue reading

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What allows TEMPERATURE (of the environment) to influence the developmental pathways that determine sex?

It is well known that the sex (i.e. whether it’s male or female gender) of certain reptiles can be determined by ambient temperatures of the environment, although the precise molecular mechanism has remained elusive. What is it –– that allows … Continue reading

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Whole-genome sequencing (WGS) studies: Implications for autism spectrum disorder

Whole-genome sequencing (WGS) is becoming increasingly common for investigating the full spectrum of genetic variation, associated with relatively common complex diseases (e.g. obesity, cancer, autism spectrum disorder), but the challenges in interpreting data are considerable. Remember that complex diseases –– … Continue reading

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Microglial control of astrocytes in response to microbial metabolites: AHR participates in CNS inflammation (e.g. multiple sclerosis)

Authors [see attached article] identified positive and negative regulators that mediate the means by which microglia [cells in the glia of brain that function as macrophages (scavengers) in the central nervous system (CNS)] control astrocytes (star-shaped glial cells in the … Continue reading

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Whole-genome sequencing (WGS) studies: Implications for autism spectrum disorder

Whole-genome sequencing (WGS) is becoming increasingly common for investigating the full spectrum of genetic variation, associated with relatively common complex diseases (e.g. obesity, cancer, autism spectrum disorder), but the challenges in interpreting data are considerable. Remember that complex diseases –– … Continue reading

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Plain-language medical vocabulary for “precision diagnosis”

Following up on the most recent GEITP email about “precision medicine” or “personalized medicine,” this brief letter [see attached] concerns “precision diagnosis.” Often discussed in these GEITP pages have been genome-wide association studies (GWAS) in which one or more genes … Continue reading

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