Category Archives: Center for Environmental Genetics

Involvement of mitochondrial DNA in the initiation of autoimmune disease ???

COMMENT: Dear anonymous 6th-grade teacher, This sounds like a very astute student; I wonder if one or both of her parents might have careers in some aspect of biological science or medicine? The original report of using mitochondrial DNA to … Continue reading

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Many clinical trials are not getting posted publicly, as required by law

This topic more or less falls within the theme of these GEITP pages — having to do with fraud and corruption in science; however, this editorial [see attached] is more specifically about laziness, or “lack of respecting federal existing requirements.” … Continue reading

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A “sensory appendage protein” protects malaria vectors from pyrethroids ??

The wide distribution of insecticide-treated mosquito nets — over the past two decades, across malaria-endemic regions — has markely decreased the incidence of malaria, saving probably millions of lives. Recently, however, malaria-carrying mosquitoes have now been found to have developed … Continue reading

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Mullti-omics profiling of mouse gastrulation at single-cell resolution

From time-to-time, these GEITP pages have discussed topics of developmental biology (such as this paper) — because there are many similarities to evolution (and both involve gene-environment interactions). Early mammalian developmental stages include: [a] Zygotic stage (zygote is formed when … Continue reading

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HAPPY NEW YEAR OF THE RODENT

25 January 2020: HAPPY NEW YEAR OF THE RAT (or mouse, … or rodent) — These GEITP pages think that the MOUSE is much cuter than the RAT. 😊 Kingdom Animalia Phylum Chordata Class Mammalia Order Rodentia Family Muridae Genus … Continue reading

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Scientists discover ‘why stress turns hair white’

This news article — published this week in BBC.com — is an example of the gene-environment interactions theme of these GEITP pages. In this case, the environmental signal is “stress”, and the genes that respond to this signal include a … Continue reading

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Corrupting Medical Education

In keeping with these GEITP pages sometimes discussing fraud and corruption in science — the attached article by Jane M. Orient, MD (who practices internal medicine in Tucson AZ, and serves as executive director of Assn Am Physicians & Surgeons … Continue reading

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Adaptive mutability of colorectal cancers in response to targeted drug therapy

Mutagenesis (process that enhances the number of DNA mutations) can drive carcinogenesis (initiation of cancer formation) and continue during cancer progression — generating intra-tumor genetic heterogeneity that enables cancer cells to adapt, via Darwinian evolution. Analyses (e.g. mutational signature characterization) … Continue reading

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Stepwise oxygenation of Earth is an inherent property of global biogeochemical cycling

Geological studies of ancient Earth have indicated that, when the planet began 4.54 billion years ago (BYA), it was basically anaerobic (i.e. very low levels of atmospheric O2). Then, the Great Oxidation Event (GOE) occurred between ~2.5 and 2.0 BYA, … Continue reading

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Scientists use stem cells from frogs to build first living robots

These GEITP pages almost always share items that have the theme of gene-environment interactions. THIS article is a bit of a stretch to encompass that theme (but bioethical issues are considered near the end). However, this story is so intriguing … Continue reading

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