Category Archives: Center for Environmental Genetics

How the microbiome challenges “our concept of self”

This commentary [attached] is enjoyable to mull over. In just this past decade, the “gut-brain-microbiome” has been exploding in significance and challlenging many concepts that clinical medicine has held for decades. Previously, we humans have always considered ourselves to be … Continue reading

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Perfluoroalkyl substances and changes in body weight and resting metabolic rate (RMR) in response to weight-loss diets: A prospective study

This is a “correlation ––> inferred-causation” epidemiological study, and I would appreciate any comments/criticisms about these findings. Perfluoroalkyl substances (PFASs) –– especially perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) –– have been in the news a lot lately, and identified … Continue reading

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A STUDY OF EVOLUTION: Different mutational rates in single human cells at pregastrulation, neurogenesis, and during aging and neurodegeneration

Any replacement of a DNA base –– in the single strand of viruses and prokaryotes (bacteria & archaebacteria), or in one of the paired strands of eukaryotes (plants, fungi & animals) –– results in a MUTATION. DNA mutations accumulate at … Continue reading

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Evolutionary Rewiring of Human Regulatory Networks by Waves of Genome Expansion

Why does a human “look different” than an elephant, which “appears different” than a frog? As these GEITP pages have often described, whereas the genotype is the genetic makeup of an organism, the phenotype (trait) is how genetic and environmental … Continue reading

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The GREAT HUMAN DIASPORA: Evidence of an early migration of modern humans leaving Africa

The editorial [attached] is titled “When did modern humans leave Africa?” Which is a bit misleading (maybe sensationalistic?) because it has been known for decades that modern human (Homo sapiens) evolved originally (from other hominid species) in southeastern Africa –– … Continue reading

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Chronic Inflammation Suppresses Immune Cells that Fight Liver Cancer

This interesting study was funded, in part, by the NIEHS-funded Superfund Research Program (SRP), Chronic Inflammation Suppresses Immune Cells that Fight Liver Cancer Researchers at the University of California, San Diego (UCSD) showed that chronic liver inflammation can promote cancer … Continue reading

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Large genome-wide association study (GWAS) identifies gene variants associated with neuroticism

Neuroticism is a relatively stable personality trait –– characterized by negative emotionality (for example, worry and guilt). Clearly the trait of neuroticism would be regarded as multifactorial, i.e. contributions of hundreds if not thousands of genes, plus epigenetic factors, plus … Continue reading

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Large genome-wide association study (GWAS) identifies protein-altering variants associated with BMI and energy intake, in obesity

Obesity is an inherited multifactorial trait –– which reflects the contribution of genetics (DNA sequence variants), epigenetic factors (DNA-methylation, RNA-interference, histone modifications, and chromatin remodeling), plus environmental effects (diet, lifestyle, in utero environment during the pregnancy, drug-drug interactions, chronic diseases, … Continue reading

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Clostridium difficile (C diff) prevalence is enhanced by dietary trhalose-containing foods !!

Between 2001 and 2006, epidemic strains of the bacterium Clostridium difficile (C.diff) –– which can persist in some patient’s bowel and cause dangerous diarrhea, unexpectedly emerged in the United States, Canada, and several European countries. Most of these strains originated … Continue reading

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Characterizing the single-cell DNA methylome of mouse and human preimplantation embryos

As these GEITP pages have often stated, a trait (phenotype) reflects the contribution of genetics (DNA sequence differences) plus epigenetics (chromosomal changes other than DNA sequence) plus adverse environmental insults that constantly affect DNA sequence and epigenetic variations. Epigenetics includes … Continue reading

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