Category Archives: Center for Environmental Genetics

Gene-by-environment interactions in urban populations modulate risk phenotypes

Environmental exposures, coupled with genetic variation, are known to have an effect on disease susceptibility. Dissecting their respective contributions remains one of the principal challenges in understanding complex diseases. Individuals with different genotypes (DNA sequence changes) may respond differently to … Continue reading

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More information about “predatory online open-access journals

Thanks, Ken, for your remark. Beall’s List (although removed) can still be found online (and “last updated Feb 16, 2o18”). The list includes nowhere near 15,000 but it is quite a long list. https://beallslist.weebly.com/standalone-journals.html I do not see any “Journal … Continue reading

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“May the Force be with you” — Environmental signal of MECHANICAL FORCE that regulates stem cell differentiation !!

Over the past decade, advances in bioengineering have led to newly appreciated methods to study effects of mechanical force on single cells. Micrometer-scale culture systems that can subject individual cells to highly specific physical distortion have allowed scientists to demonstrate … Continue reading

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Genes involved in “degree of empathy,” — Empathy Quotient (EQ) is very much a multifactorial trait

As these GEITP pages have often described, the genetic basis of variability in any disease phenotype, in a quantitative phenotype such as height or body mass index, or in response to a drug or an environmental toxicant can be grouped … Continue reading

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Single-Cell RNA-Seq of Mouse Dopaminergic Neurons Informs Candidate Gene Selection for Sporadic Parkinson Disease

Students in grade school these days learn that DNA (containing genes) is transcribed into full-transcript RNA, which is then spliced into messenger RNA (mRNA), which gets translated into protein. By knowing the DNA sequence of any individual’s gene therefore leads … Continue reading

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Large-Scale Multi-Ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

As these GEITP pages have often emphasized –– complex diseases, quantitative phenotypes such as height or body mass index, drug efficacy or adverse effects, or toxicity caused by environmental agents –– are almost always examples of multifactorial traits. The phenotype … Continue reading

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This clinical study proposes that there should be five types of diabetes mellitus, not two

Diabetes represents a multifactorial trait –– manifested by the contribution of many genes plus epigenetic and environmental factors. Clinically, in any reasonably sized populatin, this disorder is always seen as a gradient. This [below] would appear to be a very … Continue reading

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Reconstructing an African haploid genome from the 18th century

This article is an example of what can be done by commercial DNA-sequencing cmpanies such as MyHeritage, Ancestry, Vitagene, LivingDNA, GPS Origins, 23andMe and dozens of other similar companies. The population of Iceland was founded by settlers from continental Scandinavia … Continue reading

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The expanding world of small RNAs in plants: what the heck is easiRNA ???

Gene-environment interactions in plants are often similar to those in animals, but there are also distinct differences. Small RNAs, transcribed from the DNA of a plant’s genome, are involved in plant development, repro­duction, and genome reprogramming –– as described in … Continue reading

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“DNA.Land” — a framework to collect genomes and phenomes in the present era of abundant genetic information

With publications of genome-wide association studies (GWAS) comprising increasingly larger cohorts, it has become clear that virtually all multifactorial traits (e.g. height, body mass index, type-2 diabetes, asthma, cancer, autism spectrum disorder) must reflect hundreds if not thousands of genes, … Continue reading

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