Category Archives: Center for Environmental Genetics

The NEW TREND: genome-wide association studies (GWAS) with cohorts >1 million (or many millions of) individuals

On 25 Feb 2019, these GEITP pages described “an unprecedented cohort size of more than 1 million”, in which a genome-wide association study (GWAS) was carried out to search for genes (genotype; or genetic architecture) statistically significantly (P

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“Origins of Life” have been created by a NASA experiment ???

As these GEITP pages have considered from time to time, how “life” began on Earth is relevant to gene-environment (GxE) interactions — in some ways similar to the relevance of GxE to evolution of life over the past 4+ billion … Continue reading

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Separating host and microbiome contributions to drug pharmacokinetics and drug toxicity

These GEITP pages have discussed, on several occasions, the importance of the “brain-gut-microbiome” (i.e. interaction of each patient’s gut bacteria/virus/fungus with intestine AND brain of the same patient). Of all the many ways the ecosystem of microbes (comprising 92% of … Continue reading

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Climate Change Reconsidered — Fossil Fuels II

These GEITP pages have covered not only gene-environment interactions but also fraud and corruption involving gene-environment interactions. One such example, often discussed herein, has been the governmental policy to support the Linear No-Threshold (LNT) Model — although experimental evidence is … Continue reading

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Dating of hominins living in Denisova Cave (southeastern Siberia)

These GEITP pages have often discussed evolution and dispersal (migration) of hominins (i.e. any species of early human that is more closely related to humans than chimpanzees — including modern human) during the past 6 million years. The time period … Continue reading

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NASA scientists offer new clues to how life started on Earth after reproducing the origins of life on the ocean floor in a lab

NASA scientists offer new clues to how life started on Earth after reproducing the origins of life on the ocean floor in a lab Nebert, Daniel (nebertdw) Tue 2/26, 1:37 PM I

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Genome-wide analysis of INSOMNIA in more than 1 million individuals !!!

These GEITP pages have often discussed genome-wide association studies (GWAS). GWAS are studies in which some phenotype (trait) is selected to be studied, and then thousands of individuals’ genomes are screened for statistically significant genetic loci associated with that selected … Continue reading

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How a scientist’s disputed views about pollution may change EPA

By popular demand from more than several GEITP’ers, I am sharing the Tues Feb 19th front-page article in the Los Angeles Times. Often we at GEITP have chatted about Ed Calabrese and his uncovering of the fraud surrounding the Biological … Continue reading

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Plant defense: A phytolexin (kiwellin-1) blocks metabolic activity of fungal virulence factor

This topic is an excellent gene-environment interactions example. Attack of a fungus (environmental signal) on the host (a corn plant) results in genes (responding to the environmental signal) that mobilize a chemical (kiwellin-1) to defend itself against the invading fungus. … Continue reading

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How can we optimally integrate Behavioral Medicine into Clinical Genetics and Genomics??

As a human geneticist, I have always been interested ethical behavior, i.e. in how each individual patient might agree to undergoing a particular “genetic test” versus refusing to have such a test — based on many factors (age, gender, trait … Continue reading

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