Category Archives: Center for Environmental Genetics

A new understanding as to why mutation rates vary among species

MUTATIONS (i.e. alterations in DNA nucleotides in the haploid genome, base-pairs in the diploid genome) occur when cells copy their DNA incorrectly, or fail to repair damage from chemicals (endogenous or exogenous) or radiation (environmental effects). Some mistakes are beneficial, … Continue reading

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Cis-regulatory structural variants, inherited from the father, are associated with autism

Within just this last week, these GEITP pages included several email chats about “the increasing incidence/frequency of autism spectrum disorder (ASD)” among young children, not only in the U.S. but also in countries such as South Korea. Genome-wide association studies … Continue reading

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Systematic analysis of complex genetic (GxG, GxGxG) interactions

Today, innumerable genomes (many human ethni groups, other mammals, reptiles, birds, fish, and lower organisms such as worm, fly, sea squirt, sponge, yeast and bacteria) have been sequenced (by means of whole-genome sequencing; WGS), and the precise number of “genes” … Continue reading

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Blue light like that from smartphones linked to some cancers, study finds

The article [below] is from CNNnews.com; below the layman’s article is the Abstract of the scientific paper that just appeared in Environ Health Perspect. At this point, I’ll just share this news article, as is, and sit back and wait … Continue reading

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Strengthening Transparency in Regulatory Science

In my 100+ years career of genetics/genomics, there are what is called “Quantitative Trait Loci” (QTL) and “Other.” QTLs are phenotypes that can be quantified [e.g. height, body mass index (BMI), systolic blood pressure, and hemoglobin A1c]. “Other” includes autism … Continue reading

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Photoperiodic control of seasonal plant growth is mediated by ABA, acting on cell-cell communication

About 2 weeks ago, these GEITP pages described how a plant receives a signal that “it is getting stressed by dehydration (drought).” The root-derived CLE25 peptide moves from the roots to the leaves, where it induces (leaf) stomatal closure by … Continue reading

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Strengthening Transparency in Regulatory Science

Along the lines of trying to combat fraud and corruption in scientific research, these GEITP pages from time to time have shared news on this complex subject. Yes, there is a fine line between science and politics –– when one … Continue reading

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The human noncoding genome is defined by genetic diversity

As described often in these GEITP pages (archived articles can be found at http://genewhisperer.com/, thanks to the generous time and energy of Marian Miller), the human haploid (i.e. DNA on one chromosome) genome comprises ~3.2 billion nucleotides; the diploid genome … Continue reading

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Increasing numbers of children diagnosed with AUTISM SPECTRUM DISORDER (ASD) in recent years

ASD is an extremely puzzling disorder –– undoubtedly the combination of genetics, epigenetics and environment. I just checked PubMed with the words “autism etiology review” and there are >3,400 REVIEWS alone, on this topic! The term “infantile autism” was first … Continue reading

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More children diagnosed with autism spectrum disorder (ASD) in recent years

This is a recent article from ABCnews.com. As I’ve mentioned before, in probably 10,000 pediatric patients I’ve observed over the years –– I was certain that only one child truly had autism; and the mother exhibited a schizoid personality (but … Continue reading

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