Category Archives: Gene environment interactions

Genes and the environment interacting

Double edged sword of DDT

This (Feb 2o17) article is a worthwhile read and relevant to Gene-Environment Interactions. “Too much of a good thing –– is not necessariily a good thing.” The Double-Edged Sword of DDT On Jan. 24, 2017, PBS aired a two-hour special … Continue reading

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An epigenetic mechanism might be the reason why aerobic glycolysis encourages effector T cell differentiation ??

In oncology, the Warburg effect is the observation that most cancer cells predominantly produce energy by a high rate of glycolysis [process by which glucose is converted to pyruvate plus a proton (H+); the free energy released is used to form the high-energy molecules … Continue reading

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An example of “ecological opportunity” … that does not reflect adaptive radiation or “hybrid swarm”

Here is another example of gene-environment (G x E) interactions. How does a new species expand into any new ecological environment? “Ecological opportunity” is frequently proposed as the sole ingredient for adaptive radiation into novel niches. An additional trigger may … Continue reading

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Marijuana usage appears to weaken heart muscle Nebert, Daniel (nebertdw)

This was reported yesterday on CNN News. Immediate thoughts that any scientist should consider include: ––– How important are genetic differences in THC response, between people? ––– Epidemiologically, this is a retrospective study, having various caveats. ––– “One swallow does … Continue reading

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Another major factor that must be considered in genotype-phenotype association studies: The Gut Microbiome

“Genetic architecture” is a broad term defined as everything in the chromosomes of an individual organism that underlies and contributes to the genetic basis of a phenotypic trait and all variational properties. The “trait being studied” might include obesity, type-2 diabetes, schizophrenia, height … Continue reading

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Evidence that 5p12 variant rs10941679 confers susceptibility to estrogen-receptor-positive breast cancer through FGF10 and MRPS30 regulation

Etiology (underlying causes) of breast cancer remain among the biggest mysteries in current cancer research. And, after this publication, breast cancer etiology remains as big a mystery as before. Genome-wide association studies (GWAS) have revealed increased breast cancer risk associated … Continue reading

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“Incomplete penetrance” is poorly understood in genetics

“Incomplete penetrance” is a term used in genetics to explain why “having the genotype does not always necessarily result in the phenotype (trait). Even more problematic, penetrance might be 10% or 80%. And the phenotype might be a Mendelian disorder … Continue reading

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CREBRT variant increases obesity yet decreases risk of T2D in Samoans (??)

There are many epidemiological studies showing a link between obesity and type-2 diabetes (T2D). This intriguing Nat Genet paper and News-N-Views editorial [attached] describes an exception to that rule. Samoans are a unique founder population, in part because of their … Continue reading

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Genetic and environmental risk for chronic pain and the contribution of risk variants for major depressive disorder (MDD): family studies

This findings from this study [see below] are pretty wild. And curious. Authors queried whether genetic factors and the environment you share with your nuclear family, siblings, or spouse––may determine your risk of chronic pain. Depression is also associated with … Continue reading

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Genetic architecture controlling alcohol preference in rat lines divergently bred for alcohol-loving vs alcohol-avoiding behavior

Investigations on the influence of nature vs nurture on alcoholism (Alcohol Use Disorder) in human have yet to provide a clear view on potential genomic etiologies. To address this problems, authors [see attached paper] studied high (HAD) and low (LAD) … Continue reading

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