Category Archives: Gene environment interactions

Genes and the environment interacting

Novel Cobamide Structure Perhaps More Effective at Biological Degradation of Chlorinated Compounds???

This is the summary of a recent successful Superfund Project, funded by the National Institute of Environmental Health Sciences (NIEHS). Novel Cobamide Structure Perhaps More Effective at Biological Degradation of Chlorinated Compounds? Researchers at the University of Tennessee have discovered … Continue reading

Posted in Center for Environmental Genetics, Gene environment interactions | Comments Off on Novel Cobamide Structure Perhaps More Effective at Biological Degradation of Chlorinated Compounds???

Genetic diversity of the African malaria vector, the Anopheles gambiae mosquito: evidence for recent selection in insecticide-resistant genes

This topic is very central to “gene-environment (GxE) interactions.” Plasmodium falciparum is the disease-causing protozoan parasite that causes the infectious disease MALARIA in humans and other primates (which are called “the host”), and the blood-sucking mosquito Anopheles gambiae species is … Continue reading

Posted in Center for Environmental Genetics, Gene environment interactions | Comments Off on Genetic diversity of the African malaria vector, the Anopheles gambiae mosquito: evidence for recent selection in insecticide-resistant genes

Genotype-Tissue Expression Project (GTEx) can be enhanced by bridging the gaps between genotype, gene expression, and disease

This brief overview article [attached] should interest those of you who wish to combine genotype data (DNA mutations) and gene expression (transcriptomics) with human diseases or other traits such as drug efficacy or toxicity (multifactorial traits). Identifying the molecular and … Continue reading

Posted in Center for Environmental Genetics, Gene environment interactions | Comments Off on Genotype-Tissue Expression Project (GTEx) can be enhanced by bridging the gaps between genotype, gene expression, and disease

Obesity is a factor in enhancing metastasis of cancers; losing weight can reverse this effect

Because it is quite well known that obesity is associated with inflammatory processes, it probably comes as no surprise that obesity appears to enhance cancer metastasis. Obesity affects more than 30% of adults in the U.S. Although obesity has been … Continue reading

Posted in Gene environment interactions | Comments Off on Obesity is a factor in enhancing metastasis of cancers; losing weight can reverse this effect

Air pollution (PM2.5 particles) — Are they REALLY “killing thousands in the U.S.”, or should the concern of these deaths be focused on highly polluted countries such as China, India and Africa?

“PM2.5” is the abbreviation for “Particulate Matter, 2.5 micrometers or less”. PM2.5 particles are air-pollutant particles having a diameter of 2.5 micrometers or less –– i.e. small enough to invade even the smallest airways of the human lung. In the … Continue reading

Posted in Gene environment interactions | Comments Off on Air pollution (PM2.5 particles) — Are they REALLY “killing thousands in the U.S.”, or should the concern of these deaths be focused on highly polluted countries such as China, India and Africa?

Wax moth caterpillars, which normally live in bee hives feeding on honey and wax, can digest plastic

Plastics are synthetic polymers derived from fossil oil and mostly resistant to biodegradation. Polyethylene (PE) and polypropylene (PP) represent ~92% of total plastic production. PE is largely used in packaging –– representing ~40% of total demand for plastic products, with … Continue reading

Posted in Center for Environmental Genetics, Evolution and genetics, Gene environment interactions | Comments Off on Wax moth caterpillars, which normally live in bee hives feeding on honey and wax, can digest plastic

Genetic basis of inheritance for the phenotype of monogamy and child-caring …???

Peromyscus is a diverse North American genus of mouse, with habitats ranging from arid deserts to mountainous cloud forests. Along with these tremendously disparate habitats come compa­rably variable behaviors. For example, shar­ing of parental care and social monogamy are rare … Continue reading

Posted in Center for Environmental Genetics, Evolution and genetics, Gene environment interactions | Comments Off on Genetic basis of inheritance for the phenotype of monogamy and child-caring …???

The end of the linear-no-threshold (LNT) model, after trying to keep it going for almost nine decades

This tongue-in-cheek dry humor [attached article] is designed to underscore the concept that “consensus theories” that have been set up and propagated on false or faked data will eventually become exposed for what they are. The linear dose-response relationship for … Continue reading

Posted in Center for Environmental Genetics, Gene environment interactions, Toxicology | Comments Off on The end of the linear-no-threshold (LNT) model, after trying to keep it going for almost nine decades

Prevalence and architecture of de novo mutations responsible for developmental disorders in children

Genomes of patients having severe, undiagnosed developmental disorders are well known to be enriched in damaging de novo mutations (DNMs) in developmentally important genes. The attached paper describes the whole-exome sequencing (WES) of 4,293 families containing individuals with developmental disorders. … Continue reading

Posted in Center for Environmental Genetics, Evolution and genetics, Gene environment interactions | Comments Off on Prevalence and architecture of de novo mutations responsible for developmental disorders in children

Evolving as a holobiont

During this past decade, scientists have come to realize the importance of all the bacteria, fungi, and other single-celled microorganisms living in our gastrointestinal (GI) tract. As mentioned before on these GEITP pages, total DNA content of a human includes … Continue reading

Posted in Center for Environmental Genetics, Evolution and genetics, Gene environment interactions | Comments Off on Evolving as a holobiont