Category Archives: Gene environment interactions

Genes and the environment interacting

Obesity is a factor in enhancing metastasis of cancers; losing weight can reverse this effect

Because it is quite well known that obesity is associated with inflammatory processes, it probably comes as no surprise that obesity appears to enhance cancer metastasis. Obesity affects more than 30% of adults in the U.S. Although obesity has been … Continue reading

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Air pollution (PM2.5 particles) — Are they REALLY “killing thousands in the U.S.”, or should the concern of these deaths be focused on highly polluted countries such as China, India and Africa?

“PM2.5” is the abbreviation for “Particulate Matter, 2.5 micrometers or less”. PM2.5 particles are air-pollutant particles having a diameter of 2.5 micrometers or less –– i.e. small enough to invade even the smallest airways of the human lung. In the … Continue reading

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Wax moth caterpillars, which normally live in bee hives feeding on honey and wax, can digest plastic

Plastics are synthetic polymers derived from fossil oil and mostly resistant to biodegradation. Polyethylene (PE) and polypropylene (PP) represent ~92% of total plastic production. PE is largely used in packaging –– representing ~40% of total demand for plastic products, with … Continue reading

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Genetic basis of inheritance for the phenotype of monogamy and child-caring …???

Peromyscus is a diverse North American genus of mouse, with habitats ranging from arid deserts to mountainous cloud forests. Along with these tremendously disparate habitats come compa­rably variable behaviors. For example, shar­ing of parental care and social monogamy are rare … Continue reading

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The end of the linear-no-threshold (LNT) model, after trying to keep it going for almost nine decades

This tongue-in-cheek dry humor [attached article] is designed to underscore the concept that “consensus theories” that have been set up and propagated on false or faked data will eventually become exposed for what they are. The linear dose-response relationship for … Continue reading

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Prevalence and architecture of de novo mutations responsible for developmental disorders in children

Genomes of patients having severe, undiagnosed developmental disorders are well known to be enriched in damaging de novo mutations (DNMs) in developmentally important genes. The attached paper describes the whole-exome sequencing (WES) of 4,293 families containing individuals with developmental disorders. … Continue reading

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Evolving as a holobiont

During this past decade, scientists have come to realize the importance of all the bacteria, fungi, and other single-celled microorganisms living in our gastrointestinal (GI) tract. As mentioned before on these GEITP pages, total DNA content of a human includes … Continue reading

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Double edged sword of DDT

This (Feb 2o17) article is a worthwhile read and relevant to Gene-Environment Interactions. “Too much of a good thing –– is not necessariily a good thing.” The Double-Edged Sword of DDT On Jan. 24, 2017, PBS aired a two-hour special … Continue reading

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An epigenetic mechanism might be the reason why aerobic glycolysis encourages effector T cell differentiation ??

In oncology, the Warburg effect is the observation that most cancer cells predominantly produce energy by a high rate of glycolysis [process by which glucose is converted to pyruvate plus a proton (H+); the free energy released is used to form the high-energy molecules … Continue reading

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An example of “ecological opportunity” … that does not reflect adaptive radiation or “hybrid swarm”

Here is another example of gene-environment (G x E) interactions. How does a new species expand into any new ecological environment? “Ecological opportunity” is frequently proposed as the sole ingredient for adaptive radiation into novel niches. An additional trigger may … Continue reading

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