- Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal age-related osteoarthritis (OA)
- Autoimmune diseases are more likely to appear — years after having received cancer drugs of the class “checkpoint inhibitors”
- Buying an “inbred mouse” for your experiments — might not be as homogeneous and stable, from year to year, as you think …..
- Previous history of biology preprints: A forgotten experiment from the 1960s
- Oral statins appear to help the host in combating antibiotic-resistant bacteria
Category Archives: Gene environment interactions
Because it is quite well known that obesity is associated with inflammatory processes, it probably comes as no surprise that obesity appears to enhance cancer metastasis. Obesity affects more than 30% of adults in the U.S. Although obesity has been … Continue reading
Air pollution (PM2.5 particles) — Are they REALLY “killing thousands in the U.S.”, or should the concern of these deaths be focused on highly polluted countries such as China, India and Africa?
“PM2.5” is the abbreviation for “Particulate Matter, 2.5 micrometers or less”. PM2.5 particles are air-pollutant particles having a diameter of 2.5 micrometers or less –– i.e. small enough to invade even the smallest airways of the human lung. In the … Continue reading
Wax moth caterpillars, which normally live in bee hives feeding on honey and wax, can digest plastic
Plastics are synthetic polymers derived from fossil oil and mostly resistant to biodegradation. Polyethylene (PE) and polypropylene (PP) represent ~92% of total plastic production. PE is largely used in packaging –– representing ~40% of total demand for plastic products, with … Continue reading
Peromyscus is a diverse North American genus of mouse, with habitats ranging from arid deserts to mountainous cloud forests. Along with these tremendously disparate habitats come comparably variable behaviors. For example, sharing of parental care and social monogamy are rare … Continue reading
The end of the linear-no-threshold (LNT) model, after trying to keep it going for almost nine decades
This tongue-in-cheek dry humor [attached article] is designed to underscore the concept that “consensus theories” that have been set up and propagated on false or faked data will eventually become exposed for what they are. The linear dose-response relationship for … Continue reading
Prevalence and architecture of de novo mutations responsible for developmental disorders in children
Genomes of patients having severe, undiagnosed developmental disorders are well known to be enriched in damaging de novo mutations (DNMs) in developmentally important genes. The attached paper describes the whole-exome sequencing (WES) of 4,293 families containing individuals with developmental disorders. … Continue reading
During this past decade, scientists have come to realize the importance of all the bacteria, fungi, and other single-celled microorganisms living in our gastrointestinal (GI) tract. As mentioned before on these GEITP pages, total DNA content of a human includes … Continue reading
This (Feb 2o17) article is a worthwhile read and relevant to Gene-Environment Interactions. “Too much of a good thing –– is not necessariily a good thing.” The Double-Edged Sword of DDT On Jan. 24, 2017, PBS aired a two-hour special … Continue reading
An epigenetic mechanism might be the reason why aerobic glycolysis encourages effector T cell differentiation ??
In oncology, the Warburg effect is the observation that most cancer cells predominantly produce energy by a high rate of glycolysis [process by which glucose is converted to pyruvate plus a proton (H+); the free energy released is used to form the high-energy molecules … Continue reading
Here is another example of gene-environment (G x E) interactions. How does a new species expand into any new ecological environment? “Ecological opportunity” is frequently proposed as the sole ingredient for adaptive radiation into novel niches. An additional trigger may … Continue reading