Category Archives: Gene environment interactions

Genes and the environment interacting

Bacterial death and population dynamics affect mutation-rate estimates and evolvability — in response to ENVIRONMENTAL STRESS

The topic today is directly central to “gene-environment interactions.” Three decades ago, experiments in the lab of John Cairns showed that the effect of “environmental stress” on the mutation rate in bacteria can be remarkably strong (the “stress” they used … Continue reading

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Only certain histone posttranslatinal modifications appear to qualify as “having an epigenetic effect” ???

As often covered in these GEITP pages, multifactorial traits (e.g. phenotypes such as type-2 diabetes, drug efficacy, many dose-independent adverse drug reactions, autism spectrum disorder, cancer) represent the contributions of: [a] genetic predisposition (genotype; DNA-sequence changes); [b] epigenetic effects; [c] … Continue reading

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The prehistoric peopling of Southeast Asia

Anatomically modern humans are known to have expanded into Southeast Asia at least 65,000 years ago –– leading to formation of the Hòabìnhian hunter-gatherer tradition. Although Hòabìnhian foragers are considered to be the ancestors of present-day hunter-gatherers from mainland Southeast … Continue reading

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Induction of innate immune memory: — microRNA targets chromatin-remodeling factors !!

Prolonged exposure of mouse or human immune cells to unwanted microbial products –– such as lipopolysaccharide (LPS) –– can induce a form of innate immune memory that suppresses subsequent responses to unrelated pathogens. This is called “LPS tolerance”. Sepsis (presence … Continue reading

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Parallel altitudinal clines reveal trends in adaptive evolution of genome size in domesticated maize (Zea mays)

GENOME SIZE varies by several orders of magnitude across species, due to both changes in ploidy (number of sets of homologous chromosomes that make up the genome of a cell or an organism) as well as haploid DNA content (one-half … Continue reading

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Triggers of tree mortality under drought conditions

This is a gene-environment interactions topic. The “environmental signal” in this case is DROUGHT. Which genes in the tree’s genome will respond to the drought signal in order for the tree to survive? Forests provide a wide array of ecosystem … Continue reading

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Decades of Mismanagement Turned US Forests into ‘Slow-Motion Time Bombs’

Decades of Mismanagement Turned US Forests into ‘Slow-Motion Time Bombs’ wildfire calif Bob Zybach [PhD in Forestry. Oregon State University Environmental Sciences Program] feels like a broken record. Decades ago he warned government officials allowing Oregon’s forests to grow unchecked … Continue reading

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Novel Cobamide Structure Perhaps More Effective at Biological Degradation of Chlorinated Compounds???

This is the summary of a recent successful Superfund Project, funded by the National Institute of Environmental Health Sciences (NIEHS). Novel Cobamide Structure Perhaps More Effective at Biological Degradation of Chlorinated Compounds? Researchers at the University of Tennessee have discovered … Continue reading

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Genetic diversity of the African malaria vector, the Anopheles gambiae mosquito: evidence for recent selection in insecticide-resistant genes

This topic is very central to “gene-environment (GxE) interactions.” Plasmodium falciparum is the disease-causing protozoan parasite that causes the infectious disease MALARIA in humans and other primates (which are called “the host”), and the blood-sucking mosquito Anopheles gambiae species is … Continue reading

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Genotype-Tissue Expression Project (GTEx) can be enhanced by bridging the gaps between genotype, gene expression, and disease

This brief overview article [attached] should interest those of you who wish to combine genotype data (DNA mutations) and gene expression (transcriptomics) with human diseases or other traits such as drug efficacy or toxicity (multifactorial traits). Identifying the molecular and … Continue reading

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