Category Archives: Evolution and genetics

Distribution of H3K4me3/H3K27me3 chromatin in male germ cells of six vertebrate species: evidence as to what specifies animal development

The nomenclature of chromatin containing the H3 family of histones, the amino acid lysine (K), at amino acid residue position 4 (counting from the N-terminus), having three methyl groups added (m3) is abbreviated “H3K4me3”. The attached paper tracks the distribution … Continue reading

Posted in Center for Environmental Genetics, Evolution and genetics | Comments Off on Distribution of H3K4me3/H3K27me3 chromatin in male germ cells of six vertebrate species: evidence as to what specifies animal development

Parent-of-origin-specific signatures of de novo mutations (DNMs)

De novo mutations (DNMs) originating during gametogenesis (when the sperm and oocyte are formed) are an important source of genetic variation. The process of gametogenesis is quite different between males and females. The sperm produced by a 20-year-old male has … Continue reading

Posted in Center for Environmental Genetics, Evolution and genetics, Gene environment interactions | Comments Off on Parent-of-origin-specific signatures of de novo mutations (DNMs)

Contrary to expectation, low-frequency and rare genetic variants do NOT contribute significantly to type-2 diabetes risk ??

The reason for continual GEITP interest in multifactorial traits, such as human complex diseases including type-2 diabetes (T2D), is that many environmental-toxicant-caused diseases––as well as at least some adverse drug reactions––also qualify as multifactorial traits (meaning ‘phenotypes having contribution from … Continue reading

Posted in Center for Environmental Genetics, Evolution and genetics | Comments Off on Contrary to expectation, low-frequency and rare genetic variants do NOT contribute significantly to type-2 diabetes risk ??