Author Archives: DWN

Complex signal processing in synthetic gene circuits using cooperative regulatory assemblies

Genes generally provide the information (in the form of RNA that is transcribed from the DNA) that ultimately leads to translation of the mRNA into protein, the gene product. Environmental signals act in numerous ways to compel transcription factors (TFs) … Continue reading

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Is Archebacteria? or Eubacteria? the ancestor of Eukaryotes ??

Before the mid-1970s, evolution (or “The Tree of Life”) was simple: everything was divided up into “animals, plants, and bacteria.” Or, “eukaryotes” (having paired chromosomes inside a nucleus with a membrane to separate it from cytoplasm) and “prokaryotes” (having single … Continue reading

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Tracking Five Millennia of “Horse Management” with Extensive Ancient Genome Time Series

Continuing along the theme of evolution, from where did the domestic horse arise? We all know that horses afforded humans with the first opportunity to spread genes, diseases, and culture much faster than humans could do on foot. Horses remained … Continue reading

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No Support for Historical Candidate Gene-by-Interaction Hypotheses for Major Depression across Multiple Large Samples

Major depressive disorder (MDD) is a VERY complex multifactorial trait in psychiatry — which is known to be “moderately” heritable. Based on identical vs fraternal twin studies, estimates of heritability are ~37%. With multifactorial traits (contributions to any phenotype by … Continue reading

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Spontaneously slow-cycling subpopulations of human cells originate from activation of stress-response pathways

This topic is an example of gene-environment interactions in which the environment is either “advantageous” or “adverse,” and genes (within each individual cell), especially those controlling cell cycle, respond to these environmental signals by speeding up, or slowing down the … Continue reading

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Starlink

For anyone who has not heard this incredible news — this is AMAZING….!!!! I had not heard one word about this. We’ll have thousands of low-orbit satellites (apparently in a string? Almost like having a ring around Earth, like Saturn … Continue reading

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SpaceX Launches 60 Starlink Internet Satellites into Orbit

This (article from the NYT) gives a whole new meaning to the children’s poem — “Star light, star bright, first star I see tonight, …………”   DwN SpaceX Launches 60 Starlink Internet Satellites into Orbit If the mission is successful, … Continue reading

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Transplanting gut bacteria alters depression-related behavior, brain inflammation in rats

This is an intriguing recent article from ScienceDaily.com Scientists have shown that transplanting gut bacteria — from a rat that is vulnerable to social stress, to a non-stressed rat — can cause vulnerable behavior in the recipient. The research reveals … Continue reading

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Rapid plant evolution is driven by interaction of pollination and herbivory

Probably most people don’t think of this, but angiosperms (flowering plants) “evolve over time” — in response a balance between how and which insects pollinate them, and herbivory (how and which animals eat them). “Pollination success” and “mating systems” are … Continue reading

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Asteroid data from the Hayabusa2 mission support collisional evolution of a pristine body

The Japanese spacecraft Hayabusa began its >2-billion-mile journey (in Dec 2014) to rendezvous and land on a rocky body with a diameter of no more than a kilometer; it arrived on Asteroid Ryugu in June 2018, and various studies are … Continue reading

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