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- Previously unappreciated form of cell-to-cell communication might be related to prions and may participate in cancer metastasis and infections
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Author Archives: DWN
Parental influence on human germline de novo mutations in 1,548 trios from Iceland
DNA mutations (alteration of a nucleotide base) can occur in the germline or somewhere in the body other than the germ cells (spermatozoa and ova). The former are called germ cell mutations, and the latter somatic cell mutations. It has … Continue reading
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60 years ago this month, Francis Crick changed the logic of Biology
For all you History of Biology and the Gene buffs, this article [attached] is a must-read. Sept 2o17 marks the 60th anniversary of one of the most significant lectures in the history of biology; it was given on 19 September … Continue reading
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Gene-environment interaction study of body mass index (BMI) reveals interactions between genetic factors and physical activity, alcohol consumption, and socioeconomic status
Genome-wide association studies (GWAS) are used for attempting to find genes/genetic loci associated with a phenotype (trait). The trait chosen to be studied might be height, weight or body mass index (BMI) –– or a complex disease such as schizophrenia, … Continue reading
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CRISPR/Cas9-edited correction of an autosomal dominant gene mutation responsible for hypertrophic cardiomyopathy (cause of sudden death in otherwise healthy young athletes)
The CRISPR/Cas9-edited correction of an autosomal dominant gene mutation (2 August 2o17 Nature paper –– reported by GEITP Sept 7; see way below and attached pdf files) now seems to be questioned by a number of other researchers in the … Continue reading
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Predatory journals are even able sometimes to scam some senior scientists who should know better
GEITP emailings have frequently covered this topic of “predatory” “online, open-access” journals that have exploded in the past few years and now number more than 8,000 (some estimates are as high as 15,000). Pseudoscientific “editors” and “publishers” of predatory journals … Continue reading
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Obesity is a factor in enhancing metastasis of cancers; losing weight can reverse this effect
Because it is quite well known that obesity is associated with inflammatory processes, it probably comes as no surprise that obesity appears to enhance cancer metastasis. Obesity affects more than 30% of adults in the U.S. Although obesity has been … Continue reading
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Genome-wide association study (GWAS) of gestational duration and spontaneous preterm birth
“Preterm birth” is defined as “birth at less than 37 completed weeks of gestation”. Prematurity used to be viewed as an “unpredictable and inevitable fact of life”. Medical efforts have thus focused on improving the consequences of prematurity rather than … Continue reading
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How to write a sincere-sounding (yet cleverly deceptive) Letter of Recommendation ; )
Just about every one of us has had to deal with “that problematic Letter of Recommendation” –– when it becomes time for your undergrad student or technician or senior staff member or grad student or postdoc to “move on” to … Continue reading
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Prevention of newborn infections and systemic sepsis by using probiotics in an India rural population
“Sepsis” is a clinical syndrome characterized by systemic inflammation and circulatory compromise initiated by an infection. For those of us who have experienced working in newborn and premie nurseries, especially in county hospitals or rural settings, we know well that … Continue reading
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CRISPR/Cas9-edited correction of an autosomal dominant gene mutation responsible for hypertrophic cardiomyopathy (cause of sudden death in otherwise healthy young athletes)
This is a follow-up of the layman’s article that GEITP previously shared on Aug 3 [from The New York Times, see below]. To reiterate, autosomal dominant mutations are inherited (from parent to child) as a single copy of a defective … Continue reading
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