Author Archives: DWN

Repurposed Antidepressant Shows Early Promise in COVID-19 Megan Brooks November 19, 2020 Read Comments Early treatment with the antidepressant fluvoxamine (Luvox) may help prevent respiratory deterioration in patients with mild symptomatic COVID-19, results of a preliminary randomized controlled trial suggest. … Continue reading →

This topic involves gene-environment interactions. Octinoxate (a sunscreen) is the “environmental signal”, and genetic activation via aryl hydrocarbon receptor (AHR)-signaling represents the “response to the signal.” We are constantly exposed to varying levels of ultraviolet radiation (UVR) from the sun … Continue reading →

Exciting new breakthrough in our understanding? These articles might be of interest to some of you. SARS-CoV-2 binds not only to ACE, but also to neuropilin receptor-1. —DwN In silico identification and validation of inhibitors of the interaction between neuropilin … Continue reading →

Bladder cancer ranks as the ninth most common malignant tumor worldwide. Cigarette smoking is among factors known to be associated with increased risk — with smokers exhibiting 3-fold higher risk of developing bladder cancer than nonsmokers. In addition, chronic exposure … Continue reading →

This topic involves gene-environment interactions. Octinoxate (a sunscreen) is the “environmental signal”, and genetic activation via aryl hydrocarbon receptor (AHR)-signaling represents the “response to the signal.” We are constantly exposed to varying levels of ultraviolet radiation (UVR) from the sun … Continue reading →

This topic is within the theme of gene-environment interactions. The “environmental signal” is — loss of a body part. ☹ The “response to that signal” is — let’s mobilize our transcription factors and regulatory elements and activate our genetic networks … Continue reading →

At first glance, this topic might not seem to be related to the GEITP theme of gene-environment interactions. However, the “environmental signal” (in this case, an endogenous compound from cells other than the target neurons) is a “somnogenic factor” and … Continue reading →

This timely article (surprisingly, from The New York Times) fits very nicely with GEITP’s gene-environment interactions theme. The author writes very clearly and eloquently, with elegant similes. And his approach (in this article) is the same way that we should … Continue reading →

This study might be of interest to some GEITP’ers. Perhaps the most significant news in this study — is that both drugs are already FDA-approved, over-the-counter (OTC), and easy to acquire. 😊 DwN Antihistamines May Help Calm COVID-19 Cytokine Storm … Continue reading →

Today we have a “natural” as a topic for gene-environment interactions. And “prions” are mentioned again — just after an article about prions 2-3 days ago in these GEITP pages. Today the “environmental signal” is temperature (heat vs cold), and … Continue reading →