Author Archives: DWN

Health predictions based on polygenic risk scores: reasonable? or too controversial?

As these GEITP pages have often discussed, genome-wide association studies (GWAS) have been used for well over a decade now –– in an attempt to determine which genes contribute to a complex trait (e.g. schizophrenia, type-2 diabetes, obesity cancer), or … Continue reading

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Down-regulation of complexin is associated with ivermectin resistance in body lice

Lice (Anoplura) are obligate blood-feeding ectoparasites of mammals; humans are the preferred host for at least two species –– Pthirus pubis and Pediculus humanus. The latter has significant relevance to public health, including head lice (living in the hair) and … Continue reading

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Privacy concerns over DNA being used for crime investigations

As many of you are probably aware –– in April, 2018, a suspect in California’s notorious “Golden State Killer” cases was arrested, after decades of eluding the police [see attached article + editorial]. Using a novel forensic approach (using an … Continue reading

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Accurate classification of almost 4,000 SNVs in BRCA1 gene : An example of “saturation genome-editing”

The breast cancer susceptibility gene BRCA1, was first identified and named in 1994. Initially it was declared “THE gene that causes breast cancer” –– but then, shortly thereafter, it became clear that some mutations in this gene contribute ~5% to … Continue reading

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Neaderthal genes have helped Homo sapiens in defending against viral infections

From DNA-sequencing studies of intact cells in hominid fossils (combined with geological-dating evidence where the fossil was located), it is now accepted that modern human (Homo sapiens) diverged from Neaderthal (Homo neaderthalensis) ~600,000 years ago. Several studies have also shown … Continue reading

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Intestinal barrier dysfunction orchestrates onset of inflammatory host-microbiome cross-talk (in a human gut inflammation-on-a-chip)

These GEITP pages have frequently discussed the growing realization of the “brain-gut-microbiome” importance in clinical health and disease. Human intestinal inflammation involves complex processes: mucosal injury, impaired barrier function, recruitment and infiltration of immune cells, and subsequent inflammatory responses that … Continue reading

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Muller’s Nobel prize research lacked peer review — which culminated in the linear no-threshold (LNT) Model, still being relied upon, by many, today

These GEITP pages have continued to follow the saga (by Ed Calabrese) –– in uncovering a certain amount of deception (during the 1920s-30s-40s) that led to an undeserved Nobel Prize in Physiology or Medicine. To reiterate briefly, Hermann Joseph Muller … Continue reading

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Intestinal barrier dysfunction orchestrates onset of inflammatory host-microbiome cross-talk (in a human gut inflammation-on-a-chip)

These GEITP pages have frequently discussed the growing realization of the “brain-gut-microbiome” importance in clinical health and disease Human intestinal inflammation involves complex processes: mucosal injury, impaired barrier function, recruitment and infiltration of immune cells, and subsequent inflammatory responses that … Continue reading

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Genetics and academic success at university

From time to time, these GEITP pages feature one or another genome-wide association study (GWAS). A genotype-phenotype association can be virtually anything that the scientific group decides to study. In the present case, genes [examining several million single-nucleotide variants (SNVs) … Continue reading

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When Adolescents Give Up Pot, Their Cognition Quickly Improves

This article [yesterday on the National Public Radio (NPR) web site] just confirms further what some have been saying about Cannabis (marijuana; most active ingredient is tetrahydrocannabinol) for at least the past decade. First, there was evidence in mice, then … Continue reading

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