Author Archives: DWN

Population Histories of the United States Revealed through Fine-Scale Migration and Haplotype Analysis

These GEITP pages, from time-to-time, have discussed issues of human evolution and global migration; this topic represents one of the latter group. The U.S. population represents tremendous diversity of global ancestries — shaped by migration from distant continents, plus admixture … Continue reading

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Parallel and nonparallel genomic responses contribute to herbicide resistance in a common agricultural weed

Here is a made-to-order topic of gene-environment interactions: the environmental signal is an “herbicide”, and genetic networks must quickly “adapt” [i.e. find a means of combatting this toxicant (the “response”)] — or else the plant will not survive. Pesticide resistance … Continue reading

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AKI in SARS-CoV-2 infection

The letter below is a request to any GEITP clinicians (pulmonologists, cardiologists or GI specialists) who know of someone who is, or who are, treating a substantial number of COVID-19 patients. Professor Soleimani ( Univ of New Mexico in Albuquerque.) … Continue reading

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Estimating excess mortality in people with cancer and multimorbidity in the COVID-19 emergency

The attached manuscript by a British group was embargoed until this morning. Appearing today on ResearchGate, this is a COVID-19 rapid communication, a preprint (Fred’s favorite kind, not peer-reviewed). Conclusions are that the COVID-19 emergency in England could result in … Continue reading

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The race for coronavirus vaccines: a graphical guide

These diagrams came out today in Nature Rev Drug Disc http://doi.org/ggrnbr (2020). These are great diagrams. 😊 Contributed by a fellow GEITP-er, for everyone to share. If anyone wants a pdf of the entire paper, please ask. The race for … Continue reading

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Personalized Prognostic Prediction of Treatment Outcome for Depressed Patients in a Realistic Psychiatric Hospital Setting: A Comparison of Machine-Learning Approaches

This topic follows our gene-environment interactions theme. The “environmental signal” is the type of treatment, and the “response” (undoubtedly reflected in the expressivity of hundreds of genes) is “clinical outcome” in the patient. Research on “how to predict treatment outcome” … Continue reading

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EPIDEMIOLOGIST EXPLAINS COVID-19

To interject a bit of levity into these ongoing discussions of the SARS-CoV-2 virus causing COVID-19 disease in some patients — this short youtube video was offered by one of our GEITP-ers. [The language of the video is Australianese, so … Continue reading

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Physicians now hesitant to treat COVID-19 as a high-altitude pulmonary edema (HAPE) syndrome

To follow-up on the previous claims that COVID-19 “might be more closely related to a high-altitude pulmonary edema (HAPE) — than an acute respiratory distress syndrome (ARDS) presentation” — knowledgeable experts [see article from Medscape below] are saying that each … Continue reading

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We are all related to Charlemagne ??

These GEITP pages have often discussed evolution, and quite often evolution of Homo sapiens during the Great Human Diaspora (migrations out of Africa, multiple times, and repeated admixture of sublines). Today, even seemingly unrelated humans are distant cousins to each … Continue reading

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Paternal Δ9-Tetrahydrocannabinol Exposure in Rats Prior to Mating Elicits Deficits in Cholinergic Synaptic Function in Offspring

This topic involves gene-environment interactions. The environmental signal is Δ9-tetrahydrocannabinol exposure (THC) to the male rat prior to mating; response in the offspring’s brain to the signal represents changes in phenotype, probably reflecting epigenetic effects caused by the THC. Authors … Continue reading

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