Author Archives: DWN

Interface Newsletter: Issue 32 — summer and fall 2006

IN THIS ISSUE Cough Syrup Disaster…………………1 Evolutionarily Speaking……………….4 Latest in Genetics and Genomics…….7 Human Variation………………………..7 Biotechnology…………………………………8 Observations by a Biologist…………….9 Ethical, Legal and Social Issues……10 Letters to the Editor……………………….12 Gene-Environment Tidbits………….5 Welcome, New Director ……………..11

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Interface Newsletter: Issue 9 — fall 1996

IN THIS ISSUE Environmental Pollution and Child Health in Central and Eastern Europe……………………………………………….1 Letters to the Editor…………………………….3 Happy Birthday to You………………………..5 CEG Members in the News…………………..6 Jigsaw Puzzle Gene……………………………..6 CEG-Sponsored Speakers…………………….6 Science Lite………………………………………..7 Observations by a Biologist………………….8 Who Should Regulate … Continue reading

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Novel Cobamide Structure Perhaps More Effective at Biological Degradation of Chlorinated Compounds???

This is the summary of a recent successful Superfund Project, funded by the National Institute of Environmental Health Sciences (NIEHS). Novel Cobamide Structure Perhaps More Effective at Biological Degradation of Chlorinated Compounds? Researchers at the University of Tennessee have discovered … Continue reading

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Multi-ethnic genome-wide association study (GWAS) reveals polygenic architecture of earlobe attachment

I can still remember the day when one of my sons (and he was certainly no more than 6 years old) was deep in thought and then asked, “How many genes do you think it would take to make a … Continue reading

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High-throughput annotation of full-length long noncoding RNAs (lncRNAs) — success using RNA Capture Long Seq (CLS)

Long noncoding RNAs (lncRNAs), formerly called “long intergenic noncoding RNAs” (lincRNAs), represent a vast and relatively unexplored component of the mammalian genome. They are defined as “>200 nucleotides, and up to many thousands of nucleotides, that are transcribed into RNA … Continue reading

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Decreased mutation rate in exons — discovered to be due to differential DNA mismatch repair

A mutation usually means “the change in one base” [one nucleotide in the haploid genome; one base-pair (bp) in the diploid genome], but sometimes “mutations” can include any changes –– from a single bp alteration to many bases (two, five, … Continue reading

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Maternal age elicits phenotypic variation in the Caenorhabditis elegans (nematode)

For years, on these pages of “Gene-Environment Interactions,” we’ve pointed out that the genotype [dependent on: DNA alterations (i.e. genetics), epigenetic changes (i.e. DNA-methylation, RNA-interference, histone modifications, chromatin remodeling), adverse environmental effects, and even obscure (poorly understood) transgenerational effects] reflects … Continue reading

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Genetic diversity of the African malaria vector, the Anopheles gambiae mosquito: evidence for recent selection in insecticide-resistant genes

This topic is very central to “gene-environment (GxE) interactions.” Plasmodium falciparum is the disease-causing protozoan parasite that causes the infectious disease MALARIA in humans and other primates (which are called “the host”), and the blood-sucking mosquito Anopheles gambiae species is … Continue reading

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Asian perspectives on the origin of modern human populations

In spite of the general acceptance that modern humans (Homo sapiens) arose in Africa, information about the initial arrival and survival of modern humans in different areas of the world continues to be discovered and updated. Over the past several … Continue reading

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Genotype-Tissue Expression Project (GTEx) can be enhanced by bridging the gaps between genotype, gene expression, and disease

This brief overview article [attached] should interest those of you who wish to combine genotype data (DNA mutations) and gene expression (transcriptomics) with human diseases or other traits such as drug efficacy or toxicity (multifactorial traits). Identifying the molecular and … Continue reading

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