Author Archives: DWN

A Commericial Sunscreen Modulates Aryl Hydrocarbon Receptor-Signaling in Keratinocytes and Inhibits CYP1A1 and CYP1B1 Enzyme Activities

This topic involves gene-environment interactions. Octinoxate (a sunscreen) is the “environmental signal”, and genetic activation via aryl hydrocarbon receptor (AHR)-signaling represents the “response to the signal.” We are constantly exposed to varying levels of ultraviolet radiation (UVR) from the sun … Continue reading

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new binding target for SARS-CoV-2

Exciting new breakthrough in our understanding? These articles might be of interest to some of you. SARS-CoV-2 binds not only to ACE, but also to neuropilin receptor-1. —DwN In silico identification and validation of inhibitors of the interaction between neuropilin … Continue reading

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Effects of Arsenic (+3 Oxidation State) Methyltransferase Gene Polymorphisms and Risk of Bladder Cancer

Bladder cancer ranks as the ninth most common malignant tumor worldwide. Cigarette smoking is among factors known to be associated with increased risk — with smokers exhibiting 3-fold higher risk of developing bladder cancer than nonsmokers. In addition, chronic exposure … Continue reading

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A Commericial Sunscreen Modulates Aryl Hydrocarbon Receptor-Signaling in Keratinocytes and Inhibits CYP1A1 and CYP1B1 Enzyme Activities

This topic involves gene-environment interactions. Octinoxate (a sunscreen) is the “environmental signal”, and genetic activation via aryl hydrocarbon receptor (AHR)-signaling represents the “response to the signal.” We are constantly exposed to varying levels of ultraviolet radiation (UVR) from the sun … Continue reading

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Changes in regeneration-responsive enhancers affect regenerative capacities in vertebrates

This topic is within the theme of gene-environment interactions. The “environmental signal” is — loss of a body part. ☹ The “response to that signal” is — let’s mobilize our transcription factors and regulatory elements and activate our genetic networks … Continue reading

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Regulation of sleep homeostasis mediator (adenosine) in the mouse — mostly by glutamatergic neurons

At first glance, this topic might not seem to be related to the GEITP theme of gene-environment interactions. However, the “environmental signal” (in this case, an endogenous compound from cells other than the target neurons) is a “somnogenic factor” and … Continue reading

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The pandemic—from the virus’ point-of-view

This timely article (surprisingly, from The New York Times) fits very nicely with GEITP’s gene-environment interactions theme. The author writes very clearly and eloquently, with elegant similes. And his approach (in this article) is the same way that we should … Continue reading

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Antihistamines May Help Calm COVID-19 Cytokine Storm

This study might be of interest to some GEITP’ers. Perhaps the most significant news in this study — is that both drugs are already FDA-approved, over-the-counter (OTC), and easy to acquire. 😊 DwN Antihistamines May Help Calm COVID-19 Cytokine Storm … Continue reading

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Prion-like domain in ELF3 acts as a thermosensor in the plant Arabidopsis

Today we have a “natural” as a topic for gene-environment interactions. And “prions” are mentioned again — just after an article about prions 2-3 days ago in these GEITP pages. Today the “environmental signal” is temperature (heat vs cold), and … Continue reading

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Accumulation of storage proteins in plant seeds is mediated by amyloid formation

Just as “prions” were first discovered in humans — and now are realized to exist in not only all animals but also yeast, fungi and plants — and carry out important functions — so we learn [from the attached article] … Continue reading

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