Author Archives: DWN

Excellent summary from several difference scientific sources on global climate change

This is an EXCELLENT summary from several difference scientific sources — appearing in https//finance.townhall.com — that should (or could) clarify the minds of non-scientists who do not understand Climatology, and how complex it is. Anyone with an open mind, or … Continue reading

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Key metabolic gene for recurrent freshwater colonization and radiation in fish

This story is a great example of gene-environment interactions. When organisms evolve — so that they might occupy a new environment — what adaptations in the genome are required for this transition? Authors [see attached article & editorial] have determined … Continue reading

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Vision using multiple distinct rod opsins in deep-sea fishes

Why is this topic chosen for today’s GEITP email? Well, “light” is an environmental signal, and “genes” within the genome that respond to this signal, are responsible for the “vision” phenotype (trait). And, during evolution, “vision” of course was extremely … Continue reading

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Oligogenic inheritance of a human heart disease involving a genetic modifier

Noll, I stand corrected. 😊 Obviously — I am misusing the term “compound heterozygosity” (and I wondered about that, as I wrote it). Perhaps “tri-allelic recessive heterozygosity” is a better term. Or, as the authors have in the title of … Continue reading

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Study of multiethnic genomes identifies 27 genetic variants associated with disease

This article is a semi-lay summary of a publication soon to appear in Nature. As most of us would expect — the genomes of different ethnic groups exhibit ethnicity-specific alleles (mutations in at least one of the two alleles of … Continue reading

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Some thoughts on the utilization of polygenic risk scores (PRSs) for therapeutic targeting

These GEITP pages have often discussed genome-wide association studies (GWAS), in which a phenotype (i.e. trait — such as height or cancer) is selected by a research team, and then the genomes of hundreds or many thousands of subjects are … Continue reading

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Tracking humans and Their Microbiomes

As these GEITP pages have continued to emphasize: Multifactorial phenotypes — including complex diseases (e.g. type-2 diabetes, major depressive disorder), quantitative traits (e.g. body mass index, height), drug efficacy and adverse drug reactions, and responses to environmental toxicants (e.g. dioxin, … Continue reading

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The vaginal microbiome and preterm birth

As these GEITP pages have continued to emphasize: Multifactorial phenotypes — including complex diseases (e.g. type-2 diabetes, cancer, major depressive disorder), quantitative traits (e.g. height, body mass index), drug efficacy and adverse drug reactions, and responses to environmental toxicants (e.g. … Continue reading

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Zeroing in on what actually motivates — learning and motivation

Dopamine is a neurotransmitter molecule that influences brain pathways — involved in motivation, movement, reasoning/perception, and reward-driven learning. How dopamine contributes to such seemingly-unrelated varied behaviors is the topic of this GEITP email. In fact, understanding the biochemical and genetic … Continue reading

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Let’s Teach Factual Climate Science In Schools

Let’s Teach Factual Climate Science In Schools Published June 22, 2019 | By Daniel W. Nebert Daniel W. Nebert Twenty-one Oregon teenagers have spent four years urging our federal government to take action on “climate change.” They found themselves back … Continue reading

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