Author Archives: DWN

Polycomb epigenetic silencing is mediated by specific DNA-binding recruiters

Polycomb group (PcG) proteins are essential for regulation of cell identity and development in plants and animals. PcG proteins are organized into diverse Polycomb repressive complexes (PRCs), among which PRC2 is probably the best described and most evolutionarily con­served. The … Continue reading

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NIH “completes” the atlas of human DNA differences that influence gene expression

This news is a little bit misleading –– because scientists will continue to uncover increasingly more information, with each passing month and year. Wednesday, October 11, 2017 Sections of the genome, known as expression Quantitative Trait Loci (eQTL) work to … Continue reading

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The Genotype-Tissue Expression (GTEx) Project: Associations between genetic variation and gene expression in healthy tissues — Part I

These articles represent the follow-up (the scientific data) to the GEITP email of October 16th [see far below]. How does the same DNA sequence, present in virtually every cell in the body, give rise to diverse tissues that have distinct … Continue reading

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The Genotype-Tissue Expression (GTEx) Project: Associations between genetic variation and gene expression in healthy tissues — Part II

These articles represent the follow-up (the scientific data) to the GEITP email of October 16th [see far below]. How does the same DNA sequence, present in virtually every cell in the body, give rise to diverse tissues that have distinct … Continue reading

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Meta-analysis of GWAS identifies 17 new Parkinson disease (PD) risk loci: key role for autophagy and lysosomal biology ??!!??

Parkinson disease (PD) is the second most common neurodegenerative disorder (Alzheimer disease being first). The prevalence of PD is 3–4% in individuals over 80 years of age. PD is characterized by loss of dopaminergic neurons in the substantia nigra and … Continue reading

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Breast cancer genetics revealed: 72 new mutations discovered by a large consortium comprising ~300 institutions around the world

This is a layman’s report on several published papers by researchers from ~300 institutions worldwide (the scientific reports will follow later). As GEITP has shared often on these pages, breast cancer is just another of many multifactorial traits –– contributed … Continue reading

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GWAS identifies 112 new loci for body mass index (BMI), and suggesting that lymphocytes are relevant to body weight regulation and obesity …??

Obesity, which appears to be at least in part heritable, is a risk factor for various diseases. Numerous genome-wide association studies (GWAS) have identified more than 100 DNA loci associated with body mass index (BMI) –– the most commonly used … Continue reading

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Kidney-specific genetic control module (in mouse) governs endocrine regulation of the cytochrome P450 gene Cyp27b1 essential for vitamin D3 activation

The vitamin D endocrine system in mammals is very complex –– regulating mineral homeostasis via enzyme activities in the intestine, kidney, and bone. Metabolic activation of vitamin D3 to its hormonal form, 1a,25-dihydroxyvitamin D3 [1,25(OH)2D3], i.e. most potent ligand for … Continue reading

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Linkage disequilibrium (LD)-dependent architecture of human complex traits curiously shows a mechanism of negative selection

This report summarizes a project of trying to further understand human complex diseases. WHY should this topic be of interest to gene-environment interactions? As we’ve often discussed in these GEITP pages, multifactorial traits include height, body mass index, type-2 diabetes, … Continue reading

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The Mistaken Birth and Adoption of the Linear Non-Threshold (LNT) Model: An Abridged Version

As these GEITP pages have discussed a number of times, the detective work of Ed Calabrese has uncovered, and expanded upon, one of the top deceptions of all time: the purported Linear No-Threshold (LNT) Model, based on incomplete and dishonest … Continue reading

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