Author Archives: DWN

Distinguishing “genetic correlation” from “causation” — across 52 diseases and complex traits

Okay, this topic is a bit intense (dense?), so stay with me on this one. The topic has to do with pleiotropy — when a gene, or a variant of one gene, causes two or more phenotypes (traits). This phenomenon … Continue reading

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Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia

From time to time, these GEITP pages focus on the evolution of modern human, including the Great Diaspora (i.e. several waves of Homo sapiens originating in southeast Africa and migrating to Asia and Europe, along with some ‘back-migrations’). As humans … Continue reading

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Mitochondrial genetic medicine. A Perspective by Doug Wallace

Doug Wallace is a pioneer of the mitochondrial genome. I first met him at Stanford in the late 1970s and tried several times to entice him to speak at the Univ of Cincinnati in the 1990s and 2000s (never happened, … Continue reading

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The Perfect Dose

This GEITP emailing is a bit unusual because it is a recommendation of a book on the topic of “gene-environment interactions.” Right here in the University of Cincinnati College of Medicine, we have a physician-scientist –– who somehow has “enough … Continue reading

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Genetics Humor

This cartoon by Scott Nickel in Mad Magazine is kind of cute. Comment would of course have to bring up the fact that these guys are also a few percent cellulose and other wood items, a little vegetable matter and … Continue reading

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Emery and Rimoin’s Principles and Practice of Medical Genetics and Genomics (ERPPMGG) Dec, 2018

For those interested in integrating genetics/genomics into medical practice –– the latest edition (“of the ultimate resource”) can now be purchased from Amazon.com –– the eTextbook is $118.75 and the hard-cover copy is amazingly only $125. This includes ELEVEN VOLUMES … Continue reading

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FLYING — Without combustion or moving parts — IONIC WIND

This topic has little, if anything, to do with gene-environment interactions. Yet — the possibilities and potential applications of this concept might be be a game-changer to our future generations. Anyone who has watched the Star Wars movie series has … Continue reading

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Human models are needed for studying human neurodevelopmental disorders

There is a need to understand human neurodevelopmental processes and disorders — including diseases caused by, or worsened by, exposure to environmental toxicants. Animal models (especially differences between inbred mouse strains or transgenic mouse lines) can be indispensable for determining … Continue reading

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Individual variability in cardiovascular complex disease — affected by genetics and the gut microbiome

On these GEITP pages we have had a continuing dialogue on impact of the human genome vs impact of the gut microbiome — on human health, especially considering the latest advances in high-throughput deep-sequencing [also called next-generation sequencing (NGS); and … Continue reading

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Statistical pitfalls of “personalized medicine”

“Personalized medicine” has become a buzzword for many clinicians and geneticists during the past decade. Personalized medicine aims to match each individual with the (most appropriate) therapy that is “best suited to him/her for their condition” (this goal of course, … Continue reading

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