Author Archives: DWN

VDH ~ How America’s Students Need to Get ‘Woke’

This is an incredibly powerful summary of what has happened to our nation’s colleges and universities during the past three decades — eloquently and sincerely written by a Stanford professor who knows what is happening. Brilliant observations from one who … Continue reading

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Happy Holiday Season

Happy Holiday Season THESE GEITP PAGES WISH EVERYONE A JOYOUS HANUKKAH AND A MERRY CHRISTMAS AND A HAPPY NEW YEAR 2020. OUR SHARING OF SCIENTIFIC ARTICLES — WILL RESUME AFTER THE FIRST OF THE YEAR. 😊 DwN

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The Great Oxidation Event and the Lomagundi Event might have both occurred by tectonic plate movements about 2.5 billion years ago

These GEITP pages have often discussed events during evolution — which in fact occurs because of gene-environment interactions. Once the original nucleic acid formed “the first gene” (more than 4 billion years ago), all genes ever since have diverged and … Continue reading

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A Fast and Accurate Method for Genome-wide Scale Phenome-wide G × E Analysis and Its Application to UK Biobank

The etiology of most complex diseases (i.e. multifactorial traits) involves genetic variants, environmental factors, and gene-environment (GxE) interaction effects. Because of the contribution of many small-effect genes and marginal genetic association studies, GxE analysis requires large numbers of samples and … Continue reading

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Chronic Hexavalent Chromium (Cr(6+) Exposure Induces Cancer Stem Cell (CSC)-Like Properties and Tumorigenesis by Increasing c-Myc Expression

The metal chromium (Cr) is present during the manufacturing of many consumer products — plus being present in particulate matter from vehicle and other emissions. The valency states of Cr found in occupational and the general environment include Cr(0), Cr(III), … Continue reading

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Integrating Clinical Data and Imputed Transcriptome from GWAS to Uncover Complex Disease Subtypes: Applications in Psychiatry and Cardiology

A more accurate classification of complex diseases — such as psychiatric illnesses and cardiometabolic disorders — into clinically and biologically more homogeneous subtypes could perhaps facilitate the understanding of disease pathophysiology and development of more targeted interventions (i.e. drug therapy). … Continue reading

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SpaceX launch — highlights the threat of “megaconstellations that might disrupt astronomical observations”

In the late spring of 2019, these GEITP pages mentioned the SpaceX program — which turned out to be very helpful information: some of our GEITP readers saw this string of lights rapidly moving across the sky and, because they … Continue reading

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A genetically tailored education for birds learning how to sing ???

The belief that some people are born “gifted” — and others are genetically programmed to be mediocre — is deeply rooted in our culture. However, the influence of genes on learning is not straightforward. Authors [see attached article & editorial] … Continue reading

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Making the Most of Clumping and Thresholding for Polygenic Risk Scores

Fine-tuning polygenic risk scores (PRS) falls within the GEITP theme of gene-environment interactions. The ability to accurately predict disease risk (for complex diseases that involve contributions from hundreds or thousands of genes) — is one of the goals of “precision … Continue reading

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Bacteriophage-targeting of gut bacterium attenuates alcoholic liver disease

This topic is central to gene-environment interactions, i.e. the environment is “excessive alcohol drinking”, and the genes are those that attempt to protect the liver against this onslaught (the environmental signal), but the patient winds up developing alcohol-related liver disease … Continue reading

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