Author Archives: DWN

Whole-exome sequencing (WES) — of Finnish isolated populations — enhances rare-variant association power

Most alleles (recall that each gene has two ‘alleles’, one from each parent, and one on each chromosome of the chromosomal pair) — having demonstrated deleterious effects on phenotypes (traits; e.g. height, body mass index, type-2 diabetes, schizophrenia) — directly … Continue reading

Posted in Center for Environmental Genetics | Comments Off on Whole-exome sequencing (WES) — of Finnish isolated populations — enhances rare-variant association power

Intestinal infection triggers Parkinson-like disease in Pink1(-/-) knockout mice

Parkinson disease (PD) is a brain disorder characterized by problems with movement and by a loss of neuronal cells (in substantia nigra of the midbrain that produce the neurotransmitter, dopamine). Cause(s) of PD are not clear, although some evidence suggests … Continue reading

Posted in Center for Environmental Genetics | Comments Off on Intestinal infection triggers Parkinson-like disease in Pink1(-/-) knockout mice

Gene (in rice) that confers broad-spectrum resistance to a class of herbicides

Rice (Oryza sativa L.) is a staple food for almost half of the world’s population of 7.53 billion. Genetic variation revealed by characterization of genomes of the genus Oryza — including domesticated and wild species — has allowed identification of … Continue reading

Posted in Center for Environmental Genetics | Comments Off on Gene (in rice) that confers broad-spectrum resistance to a class of herbicides

Gene expression catalogue created across mammalian organ development (!!!)

It was noted in the 19th century that morphological differences between species clearly increase — as animals became more advanced on the phylogenetic scale. Understanding the molecular foundations of these patterns (i.e starting from pluripotent embryonic stem cells, how does … Continue reading

Posted in Center for Environmental Genetics | Comments Off on Gene expression catalogue created across mammalian organ development (!!!)

During early lung squamous cell cancer, immune evasion occurs before tumor invasion

Cancer is a multifactorial trait — undoubtedly with contributions from genes (genetics), epigenetic effects, environmental factors, endogenous influences, and the patient’s changing microbiome. Hence, the relevance of this topic for these GEITP pages. Understanding the biology of carcinogenesis requires deciphering … Continue reading

Posted in Center for Environmental Genetics | Comments Off on During early lung squamous cell cancer, immune evasion occurs before tumor invasion

scSLAM-seq reveals core features of transcription dynamics in single cells

Occasionally, these GEITP pages will discuss a technique that clearly will advance the field of gene-environment interactions. The technique to be discussed here is “single-cell, thiol-(SH)-linked alkylation of RNA for metabolic labeling / sequencing” (scSLAM). This is — so bear … Continue reading

Posted in Center for Environmental Genetics | Comments Off on scSLAM-seq reveals core features of transcription dynamics in single cells

How some strains of Staphylococcus aureus have evolved to resist copper toxicity

Copper (Cu) has been used to sterilize wounds and drinking water. Normal valence states of copper include Cu1+ and Cu2+. Cu is an essential nutrient in humans (in small, nontoxic amounts). The [attached] article describes how Cu can be toxic … Continue reading

Posted in Center for Environmental Genetics | Comments Off on How some strains of Staphylococcus aureus have evolved to resist copper toxicity

‘Eco-anxiety’ over climate change causing stress, panic in millions

This article, appearing just today in https://www.upi.com/Top_News/US/2019/08/28/, is very appropriate to the recent GEITP emails. The article reaffirms how psychologically serious — especially to the young mind — false propaganda about global warming can be. This article reminds me: not … Continue reading

Posted in Gene environment interactions | Comments Off on ‘Eco-anxiety’ over climate change causing stress, panic in millions

Theroa zethus caterpillars use behavior and anti-predator weaponry to disarm host plants

Caterpillars within the Notodontidae family (butterflies and moths with approximately 3,800 known species, found in all parts of the world, but mostly in the tropics, especially in the New World; they feed primarily on leaves of ‘woody’ trees and shrubs) … Continue reading

Posted in Center for Environmental Genetics | Comments Off on Theroa zethus caterpillars use behavior and anti-predator weaponry to disarm host plants

Genetics for a warming world

This email chain-evoked such a strong outcry (of support) that I feel obliged to share with everyone some of the highlights. 😊 I chose just the “top ten.” To protect everyone’s career, all comments are anonymous. Additional supportive comments, unfortunately, … Continue reading

Posted in Center for Environmental Genetics | Comments Off on Genetics for a warming world