Monthly Archives: August 2020

With COVID, When Can Schools Re-Open?

As a pediatrician, I’ve seen plenty of cases of Kawaskai disease during my clinical years in the 1960s-70s-80s. —D July 21, 2020 With COVID, When Can Schools Re-Open? Every school year, children catch illnesses at school, and so do teachers … Continue reading

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Advances in Technologies for Therapeutic messenger RNA (mRNA) Delivery

As a follow-up to an earlier GEITP email about “mRNA delivery, attempting to create vaccine production,” this excellent review [see attached] is very thorough and complete. 😊 Current clinical efforts include development of vaccines, protein replacement therapies, and treatment of … Continue reading

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COVID Immune Responses Explained

This interview — with immunologist Dr. Akiko Iwasaki — seems to these GEITP pages to be a very worthwhile update on COVID-19, possible mechanisms of its infection, possible vaccines, and gender/age/genetic differences in response to the SARS-CoV-2 virus. Therefore (warning: … Continue reading

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A Systematic Literature Review of Whole Exome and Genome Sequencing Population Studies of Genetic Susceptibility to Cancer

This extensive review [see attached] describes the use of both whole-exome sequencing [WES; i.e. protein-coding genes only; spanning ~30 Mb (megabases, million bases)], plus whole-genome sequencing (WGS; 30,000+ Mb, i.e. the entire haploid genome). The application of NGS technologies has … Continue reading

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Why and when was lactase persistence (LP) selected for? Insights from Central Asian herders and ancient DNA ..

To answer your question, Doron, the authors simply raised a philosophical (perhaps anthropomorphic?) question that cannot be answered, i.e. why Mother Nature has chosen this (genetic) form of evolutionary adaptation (for most northern Europeans) — instead of the “simpler” (at … Continue reading

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Reactive oxygen species (ROS) regulation of RAS and vulva development in the nematode (roundworm), C. elegans

This topic for these GEITP pages is a good example of hysteresis (in biology, this is a non-linear dose-response curve, where low doses are ineffective, a higher dose is beneficial, and a higher-yet dose is toxic). Examples of gases involved … Continue reading

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RNA vaccines: a novel technology to prevent and treat disease

This information is a completely new concept to these GEITP pages(!!). I recall (in the late 1970s/early 1980s, when I was still in kindergarten 😊) our lab had tried to inject large quantities of isolated mRNA — into the peritoneal … Continue reading

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How dangerous is COVID-19? A Swedish doctor’s perspective

How dangerous is COVID-19? A Swedish doctor’s perspective By: Sebastian Rushworth August 11, 2020 I want to preface this article by stating that it is entirely anecdotal and based on my experience — working as a doctor in the emergency … Continue reading

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Evolutionary success of cancers due to their induction of failed DNA repair and errors during DNA replication ???

How a cancer evolves and how mutations are generated — are highly intertwined processes, and nearly impossible to observe directly (instead, scientists are usually restricted to making inferences about them, using data from a single snapshot in time after a … Continue reading

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Identifying and Characterizing Stress Pathways of Concern for Consumer Safety in Next-Generation Risk Assessment

Historically, safety assessments of ingredients present in consumer products (e.g. cosmetics, food) have relied on apical endpoints derived from animal testing. However, ethical and regulatory considerations on excessive animal use, in addition to scientific need to use more human-relevant data, … Continue reading

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