Monthly Archives: June 2020

Accurate and Scalable Construction of Polygenic Risk Scores (PRS) in Large Biobank Data Sets; Predictive Utility of PRS for Coronary Heart Disease in 3 Racial and Ethnic Groups

As these GEITP pages have often discussed, there are relatively simple monogenic (Mendelian) traits — in which one or only a few genes contribute to the phenotype (trait) — and multifactorial traits (e.g. human complex diseases and quantitative traits such … Continue reading

Posted in Center for Environmental Genetics | Comments Off on Accurate and Scalable Construction of Polygenic Risk Scores (PRS) in Large Biobank Data Sets; Predictive Utility of PRS for Coronary Heart Disease in 3 Racial and Ethnic Groups

An epigenome-wide association study of posttraumatic stress disorder (PTSD) in US veterans implicates several new DNA methylation loci

This fascinating topic fits perfectly the theme of gene-environment interactions. The environmental “signal” is severe stress, and the response by the genome of some (but not all) individuals is to develop post-traumatic stress disorder (PTSD). In the early 1990s, “a … Continue reading

Posted in Center for Environmental Genetics | Comments Off on An epigenome-wide association study of posttraumatic stress disorder (PTSD) in US veterans implicates several new DNA methylation loci