Monthly Archives: September 2019

Whole-exome sequencing (WES) — of Finnish isolated populations — enhances rare-variant association power

Most alleles (recall that each gene has two ‘alleles’, one from each parent, and one on each chromosome of the chromosomal pair) — having demonstrated deleterious effects on phenotypes (traits; e.g. height, body mass index, type-2 diabetes, schizophrenia) — directly … Continue reading

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Intestinal infection triggers Parkinson-like disease in Pink1(-/-) knockout mice

Parkinson disease (PD) is a brain disorder characterized by problems with movement and by a loss of neuronal cells (in substantia nigra of the midbrain that produce the neurotransmitter, dopamine). Cause(s) of PD are not clear, although some evidence suggests … Continue reading

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Gene (in rice) that confers broad-spectrum resistance to a class of herbicides

Rice (Oryza sativa L.) is a staple food for almost half of the world’s population of 7.53 billion. Genetic variation revealed by characterization of genomes of the genus Oryza — including domesticated and wild species — has allowed identification of … Continue reading

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Gene expression catalogue created across mammalian organ development (!!!)

It was noted in the 19th century that morphological differences between species clearly increase — as animals became more advanced on the phylogenetic scale. Understanding the molecular foundations of these patterns (i.e starting from pluripotent embryonic stem cells, how does … Continue reading

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During early lung squamous cell cancer, immune evasion occurs before tumor invasion

Cancer is a multifactorial trait — undoubtedly with contributions from genes (genetics), epigenetic effects, environmental factors, endogenous influences, and the patient’s changing microbiome. Hence, the relevance of this topic for these GEITP pages. Understanding the biology of carcinogenesis requires deciphering … Continue reading

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scSLAM-seq reveals core features of transcription dynamics in single cells

Occasionally, these GEITP pages will discuss a technique that clearly will advance the field of gene-environment interactions. The technique to be discussed here is “single-cell, thiol-(SH)-linked alkylation of RNA for metabolic labeling / sequencing” (scSLAM). This is — so bear … Continue reading

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How some strains of Staphylococcus aureus have evolved to resist copper toxicity

Copper (Cu) has been used to sterilize wounds and drinking water. Normal valence states of copper include Cu1+ and Cu2+. Cu is an essential nutrient in humans (in small, nontoxic amounts). The [attached] article describes how Cu can be toxic … Continue reading

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