Monthly Archives: June 2019

Tracking humans and Their Microbiomes

As these GEITP pages have continued to emphasize: Multifactorial phenotypes — including complex diseases (e.g. type-2 diabetes, major depressive disorder), quantitative traits (e.g. body mass index, height), drug efficacy and adverse drug reactions, and responses to environmental toxicants (e.g. dioxin, … Continue reading

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The vaginal microbiome and preterm birth

As these GEITP pages have continued to emphasize: Multifactorial phenotypes — including complex diseases (e.g. type-2 diabetes, cancer, major depressive disorder), quantitative traits (e.g. height, body mass index), drug efficacy and adverse drug reactions, and responses to environmental toxicants (e.g. … Continue reading

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Zeroing in on what actually motivates — learning and motivation

Dopamine is a neurotransmitter molecule that influences brain pathways — involved in motivation, movement, reasoning/perception, and reward-driven learning. How dopamine contributes to such seemingly-unrelated varied behaviors is the topic of this GEITP email. In fact, understanding the biochemical and genetic … Continue reading

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Let’s Teach Factual Climate Science In Schools

Let’s Teach Factual Climate Science In Schools Published June 22, 2019 | By Daniel W. Nebert Daniel W. Nebert Twenty-one Oregon teenagers have spent four years urging our federal government to take action on “climate change.” They found themselves back … Continue reading

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Sun spotless for 33 days straight – airline travelers getting dosed with up to 70 times more radiation [than at sea level]

This information does not bode well for predictions of further “global warming” — In fact, the lowered solar activity could cause “global cooling” again. Ugh. Colder, snowier winters..?? ☹ Sun spotless for 33 days straight – airline travelers getting dosed … Continue reading

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Transgenic Metarhizium rapidly kills mosquitoes in a malaria-endemic region

Transgenic Metarhizium rapidly kills mosquitoes in a malaria-endemic region Nebert, Daniel (nebertdw) Thu 6/20, 2:07 PM The topic of today’s GEITP article is using a genetically-modified organism (GMO) to control a pest; this is an interesting “gene-environment interactions” type of … Continue reading

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New Method Proposed to Screen Chemicals Quickly for Cancer Risk

This article is a summary (Research Brief 294) of a recent project funded by the NIEHS Superfund Research Program (SRP). I contacted Dr. Monte, and our email correspondence is located below. DwN New Method Proposed to Screen Chemicals Quickly for … Continue reading

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The Polycomb-Dependent Epigenome Controls Beta-Cell Dysfunction, Dedifferentiation, and Diabetes

These GEITP pages have often discussed the fact that complex diseases almost always represent multifactorial phenotypes (traits) — (e.g. hypertension, schizophrenia, mental depressive disorder, cancer, autoimmunity, obesity, and diabetes) — which reflect contributions from genetics (alterations in DNA sequence), epigenetic … Continue reading

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Late Middle Pleistocene Denisovan mandible from the Tibetan Plateau

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Adaptive introgression enables evolutionary rescue from extreme environmental pollution

So that everyone is “on the same page,” let’s consider the classical example of horse-donkey breeding (i.e. two different species). Usually, the male donkey (jack) mates with a female horse (mare) to produce a mule (they can be either sex). … Continue reading

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