Monthly Archives: July 2018

Frequencing of Amyotrophic Lateral Sclerosis (ALS) associated with statin usage

This publication –– concerning drug efficacy vs possible association with long-term undesirable drug toxicity –– has been ruminating in my mind for some weeks, so I asked for input on the statistical analysis. Statin cholesterol-lowering drugs are among the most … Continue reading

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Eicosanoid profile rapidly changes when cells are cultured in a dish

As these GEITP pages have discussed a number of times, gene-environment interactions are best studied (in vivo) in the intact animal (or in clinical studies, i.e. in humans). Many labs study a biological model system in an isolated organ or … Continue reading

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A Molecule That Fuels Liver Cancer Development — Has Been Elucidated !!!

This VERY EXCITING BREAKTHROUGH was just reported as a Progress Report, in one laboratory that is funded by the NIEHS Superfund Research Program (SRP). The report below speaks for itself. 🙂 DwN Researchers Pinpoint Molecule Fueling Liver Cancer Development New … Continue reading

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Identifying the genes that evolved to give humans big brains

These two papers [see attached] go, hand-in-glove, with the previous GEITP article (shared yesterday) –– which described human-ape brain differences that had evolved during evolution. Human brains are characterized by a large neocortex that forms the foundation for development of … Continue reading

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The FUNGUS tells the ANT what to do and when to do it ?????

Evolution of life on Earth is usually DIVERGENT, i.e. one starts from a simple string of genes, A-C-E, which evolves (by gene duplications, inversions, insertions, deletions, rearrangments) into something more complex such as A-B-C-D-E. On the other hand, CONVERGENT evolution … Continue reading

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High altitude may have driven DNA mutation in FBN1 gene to cause short stature

Because genome-wide association studies (GWAS) are being performed with larger and larger numbers of individuals (cohorts), increasing numbers of small-effect genes (genotype) are becoming identified. Each of these genes are associated (statistically significantly) with the trait (phenotype) of “height.” At … Continue reading

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What makes a “good scientist?” Nine pitfalls of research misconduct

What makes a “good scientist?” Attached is a 3-page editorial on this topic. One of the coauthors teaches leader­ship skills and works with “troubled departments”. Toxic research environments share a handful of operational flaws and cognitive biases. Researchers and institutional … Continue reading

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