Monthly Archives: March 2018

Denisovians shaped the genome of modern Homo sapiens more than once

As detailed many times over the years on these GEITP pages, both fossil and genetic evidence indicate that Neanderthals (Homo neaderthalensis) and modern humans (Homo sapiens) evolved from a common ancestor between 500,000 and 200,000 years ago. Denisovans (Homo denisova; … Continue reading

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Large-Scale Multi-Ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

As these GEITP pages have often emphasized –– complex diseases, quantitative phenotypes such as height or body mass index, drug efficacy or adverse effects, or toxicity caused by environmental agents –– are almost always examples of multifactorial traits. The phenotype … Continue reading

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This clinical study proposes that there should be five types of diabetes mellitus, not two

Diabetes represents a multifactorial trait –– manifested by the contribution of many genes plus epigenetic and environmental factors. Clinically, in any reasonably sized populatin, this disorder is always seen as a gradient. This [below] would appear to be a very … Continue reading

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Reconstructing an African haploid genome from the 18th century

This article is an example of what can be done by commercial DNA-sequencing cmpanies such as MyHeritage, Ancestry, Vitagene, LivingDNA, GPS Origins, 23andMe and dozens of other similar companies. The population of Iceland was founded by settlers from continental Scandinavia … Continue reading

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The expanding world of small RNAs in plants: what the heck is easiRNA ???

Gene-environment interactions in plants are often similar to those in animals, but there are also distinct differences. Small RNAs, transcribed from the DNA of a plant’s genome, are involved in plant development, repro­duction, and genome reprogramming –– as described in … Continue reading

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