Monthly Archives: January 2018

Maternal age elicits phenotypic variation in the Caenorhabditis elegans (nematode)

For years, on these pages of “Gene-Environment Interactions,” we’ve pointed out that the genotype [dependent on: DNA alterations (i.e. genetics), epigenetic changes (i.e. DNA-methylation, RNA-interference, histone modifications, chromatin remodeling), adverse environmental effects, and even obscure (poorly understood) transgenerational effects] reflects … Continue reading

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Genetic diversity of the African malaria vector, the Anopheles gambiae mosquito: evidence for recent selection in insecticide-resistant genes

This topic is very central to “gene-environment (GxE) interactions.” Plasmodium falciparum is the disease-causing protozoan parasite that causes the infectious disease MALARIA in humans and other primates (which are called “the host”), and the blood-sucking mosquito Anopheles gambiae species is … Continue reading

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Asian perspectives on the origin of modern human populations

In spite of the general acceptance that modern humans (Homo sapiens) arose in Africa, information about the initial arrival and survival of modern humans in different areas of the world continues to be discovered and updated. Over the past several … Continue reading

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Genotype-Tissue Expression Project (GTEx) can be enhanced by bridging the gaps between genotype, gene expression, and disease

This brief overview article [attached] should interest those of you who wish to combine genotype data (DNA mutations) and gene expression (transcriptomics) with human diseases or other traits such as drug efficacy or toxicity (multifactorial traits). Identifying the molecular and … Continue reading

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