Monthly Archives: November 2017

Enhancer modules (affecting gene up- or down-regulation) are often not closest to the gene it regulates :(

The earliest genome-wide association studies (GWAS) immediately raised the question of what genes are the targets of the identified disease risk variants (single-nucleotide variants; SNVs), located sometimes inside a gene, but more often, located some distance upstream (or downstream) of … Continue reading

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Transplanting human cancers into mouse –> (surprise, surprise) genotype and phenotype tends to change rather quickly

Use of patient-derived models, in which part of a human tumor is transplanted into mice (also known as patient-derived xenografts, or PDXs), is gaining traction as a method to investigate tumor behavior such as “response to therapies”. Human-derived tumor models … Continue reading

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Analysis Commons, a team approach to discovery — in a big-data environment for genetic epideniology

The “Analysis Commons” –– which relies on a new team-science model for genetic epide­miology –– integrates multi-omic data and rich phenotypic and clinical information from diverse population studies into a single shared analytic platform that leverages the resources of a … Continue reading

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Manipulation of meteorological data by NOAA and NASA over the past 30-40 years – comments

First, I want to emphasize that there is a scientific field of climatology, which needs to be kept distinct from the political science field of non-scientific-based opinions and emotions. I believe that I can answer your email because (as you … Continue reading

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Register now: For the 2nd SRP webinar on Adverse Outcome Pathways (AOPs), November 29, 1 pm EST

For anyone interested, the NIEHS Superfund Research Program is inviting you to join them for the second session of the “Risk e-Learning” webinar series on Adverse Outcome Pathways (AOPs). For anyone who missed the first session (“Introduction to the Adverse … Continue reading

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The unrelenting search for historical truth

The attached fascinating article summarizes the Journey that Ed Calabrese has undertaken, for most of the past decade, leading to discovery of the discrepancies of the Linear No-Threshold (LNT) Model –– for which Hermann Müller was awarded the 1946 Nobel … Continue reading

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The dynamics of molecular evolution during 60,000 generations of the Escherichia coli (E. coli) bacterium

After the recent sharing of a GEITP report about a bird’s beak “evolving” to become longer –– to accommodate decades of birdfeeders in the gardens of England –– here is another example of “Evolution in Action.” The Escherichia coli long-term … Continue reading

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Manipulation of meteorological data by NOAA and NASA over the past 30-40 year to “make it appear like there is ‘global warming”

Over the years, in these GEITP pages, we have reported on, and tried to confront, scientific fraud and corruption. As you can see [from email by Chuck Wiese below], not only has this become rampant in the basic-science and clinical … Continue reading

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Recent “natural selection,” i.e. adaptive evolution, leading to longer bills (beaks) in the Parus major (bird)

One of the arguments by creationists is “how can there have been evolution in the past, if we see no evolution today?” However, multiple careful studies –– especially with the advent of next-generation DNA-sequencing becoming so common –– are now … Continue reading

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During the processes of senescence and cancer, cytplasmic chromatin and DNA leads to inflammation

Senescence is “a state of a cell showing (usually) irreversible cell-cycle arrest.” Senescence is often considered to be a protective response to cellular insults –– such as high levels of DNA damage or stress associated with the expression of cancer-promoting … Continue reading

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