Monthly Archives: October 2017

The Mistaken Birth and Adoption of the Linear Non-Threshold (LNT) Model: An Abridged Version

As these GEITP pages have discussed a number of times, the detective work of Ed Calabrese has uncovered, and expanded upon, one of the top deceptions of all time: the purported Linear No-Threshold (LNT) Model, based on incomplete and dishonest … Continue reading

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Beware of fake version) of the Impact Factor, which they have named the “PIF Impact Factor”

As these GEITP pages have discussed numerous times –– during the past decade at least 15,000 “predatory online open-access” journals have suddenly popped up and the “publishers” are flooding our email inboxes every day, 24-7-365, with requests that we “submit … Continue reading

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Widespread epistasis (gene-gene interactions) regulates glucose homeostasis and gene expression

The genetic basis of complex traits and diseases –– because they represent multifactorial traits –– results from the combined action of many DNA-sequence variants, plus epigenetic effects, plus environmental factors. It continues to remain unclear whether these variants act individually … Continue reading

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Contributions of Neaderthal DNA to phenotypic variation in the modern human

Neanderthals (Homo neanderthalensis) diverged from the modern human (Homo sapiens) lineage ~600,000 years ago in southeast Africa. This diagram should be helpful to “see” the various branches of the Homo tree [https://3c1703fe8d.site.internapcdn.net/newman/gfx/news/hires/2016/neanderthals.jpg]: Interbreeding between Neanderthals and early modern humans appears … Continue reading

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Las Vegas shooting: An effect of nature vs nurture ????

This article just appeared in Newsweek. This topic is, of course, highly political –– and it may or may not fit within our theme of “Gene-Environment Interactions.” But this will not impede many philosophical Deep-Thinkers from pontificating on the old … Continue reading

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Relative contribution of DNA methylation and DNA variants on protein biomarkers for human diseases

On these GEITP pages, often we have chatted about what contributes to a genetic trait (phenotype). The trait can be a relatively simple Mendelian recessive or dominant disorder, or the phenoypte can be a multifactorial trait –– such as height, … Continue reading

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Endophytes Help Poplar Trees Clean up Trichloroethylene (TCE)

This article (from the Superfund Diary this month) should be of interest to some of you. It turns out that a symbiotic microbe, living in the cells of poplar trees, is capable of very efficiently degrading a known human carcinogen, … Continue reading

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Previously unappreciated form of cell-to-cell communication might be related to prions and may participate in cancer metastasis and infections

Scientists know that some cells build wire-like extensions as a kind of temporary foothold to move themselves from place to place. But these “extensions” might in fact be involved in something far more complex [see attached article]. In 1999, cell … Continue reading

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After 13 years of planetary exploration, Cassini was programmed to crash into Saturn’s atmosphere

Although this article [attached] is not exactly on the topic of “gene-environment interactions,” the Cassini Project should boggle the mind of anyone interested in science, as well as astronomy or reading Sci-Fi books. In mid-September, after 13 years of solar … Continue reading

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RE: The monarch butterfly’s epic 3,000-mile migration

Dear Doron, The article I sent was describing a professor at Univ of Cincinnati, but I can’t say that his research was any “big breakthrough” in the field. Hundreds of biologists have studied this migratory phenomenon for decades. I recall … Continue reading

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