Monthly Archives: July 2017

Epigenome modifier drugs triggeer widespread transcription of endogenous retroviruses

As these GEITP emails have often covered, phenotypes (or ‘traits’) –– such as individual differences in height, serum cholesterol levels, schizophrenia, cancer, drug efficacy, or toxicity due to a drug or environmental toxicant –– can reflect DNA sequence variants, epigenetic … Continue reading

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Metabolic functions of cyclin kinases involved in cancer cell survival

Cellular metabolism is tightly coordinated with the needs of the existing cellular state. Dividing cells must duplicate their cellular components and synthesize large amounts of proteins, lipids and DNA. Yet how metabolic processes are regulated to efficiently generate this material … Continue reading

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AHR: “pioneer member” of the bHLH/PAS family of “sensors” of foreign and endogenous signals

The basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family comprises many transcription factors, found throughout all three kingdoms of life. The bHLH/PAS members “sense” innumerable intracellular and extracellular “signals” — including endogenous compounds, foreign chemicals, gas molecules, redox potential, photons (light), gravity, heat, and … Continue reading

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DNA from a 234-year-old oak tree has surprisingly few mutations — suggesting that plants might protect their stem cells

Because plants do not possess a proper germline in the way that animals do, undesirable mutations that occur in the soma can be passed on to gametes. In the field of plant genetics, it has generally been assumed that the … Continue reading

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Some geneticists question the ability of GWAS to find useful disease links

Genome-wide association studies (GWAS) are being used to identify possible drug targets that might help a particular human complex disease; there are also many labs attempting to use GWAS as a form of “predicting” one’s risk of a complex disease, … Continue reading

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Latest paleo-anthropological findings on the origin of Homo sapiens

One of GEITP’s (many) ongoing themes is the Great Human Diaspora –– i.e. when and how the Homo genus arose, when and how at least 25 different “fits and starts” of new branches arose/diverged and lived for tens of thousands … Continue reading

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