Monthly Archives: October 2016

ADHD epidemic

Several weeks ago I shared an article about autism spectrum disorder (ASD), an extremely rare clinical presentation 50 years ago but incredibly prevalent today. Another clinical presentatation is almost the same category is activity-deficit hyperactivity disorder (ADHD). Both of these … Continue reading

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Evidence that 5p12 variant rs10941679 confers susceptibility to estrogen-receptor-positive breast cancer through FGF10 and MRPS30 regulation

Etiology (underlying causes) of breast cancer remain among the biggest mysteries in current cancer research. And, after this publication, breast cancer etiology remains as big a mystery as before. Genome-wide association studies (GWAS) have revealed increased breast cancer risk associated … Continue reading

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Guidelines for large-scale sequence-based association studies: Lessons learned from whole-exome sequencing

Multifactorial traits include not only many complex diseases but also general parameters (e.g. height, body mass index), as well as drug adverse effects, drug efficacy, and drug toxicity. Massive parallel whole-genome sequencing (WGS) data have ushered in a new era … Continue reading

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Southern California air quality regulators mulling hike in taxes for smog reduction

Article [below] is from today’s The Los Angeles Times. Although the problem of ‘substantial amounts of particulate matter of <2.5 micrometer in diameter (PM2.5) in southern California smog’ had been a serious concern 20-40 years ago, the air has been … Continue reading

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Within the same wave out of Africa (??), Aborigines diverged from Eurasians between 50,000 and 70,000 years ago

For anyone who has visited the Outback (sometimes seen also in cities), you know that Australian Aborigines appear “quite distinct” in appearance––often displaying blue eyes and blonde hair while having brown skin and small stature. They have long been cast … Continue reading

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Disruption of an Evolutionarily Novel synaptic expression pattern in autism spectrum disorder, seen in human but not in apes ??

As I’ve said before, “autism” <<used to be>> a very rare medical diagnosis. Back in med school (~200 years ago), and for as long as I saw pediatric patients clinically (up to 1982)––among perhaps 10,000 kids––I recall seeing for certain … Continue reading

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“Acetylation reader proteins” that link acetylation signaling to genome maintenance and cancer

Heritability is the manifestation of genetic and epigenetic traits. Genetic traits include normal and mutated (alternative) DNA sequences. Epigenetic effects are chromosomal in origin but occur outside the DNA sequence; these include DNA methylation, RNA-interference (RNAi), histone modification, and chromatin … Continue reading

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Oldest fossils of microbial structures yet: 3.7 billion years ago

Formation of our planet Earth originated ~4.54 billion years ago (BYA). Early fossil studies focused principally on digging up bones; hence, the creationist has argued that Earth is only 20,000 years old, or some today say only 6,004 years old. … Continue reading

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Fractures prior to death are consistent with ‘Lucy in the Sky with Diamonds’ … falling out of a tree. (I kid you not.)

We need a little bit of levity sometimes. The fossil ‘Lucy’ represents the bones of a female of the hominin species, Australopithecus afarensis, from the Pliocene Period. About 40% of the skeleton was recovered in 1974 near the village Hadar in the … Continue reading

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Four distinct waves of human migration, between 106,000 and 29,000 years ago, appear to be associated with orbital-scale global climate swings

The Great Human Diaspora includes all worldwide migrations of humans, from their original migration(s) out of Africa––across Asia and Europe, from southeast Asia into Australia, and ultimately from northern Asian into the Americas. On the basis of fossil and archaeological … Continue reading

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