-
Recent Posts
- Gene-by-environment interactions in urban populations modulate risk phenotypes
- More information about “predatory online open-access journals
- “May the Force be with you” — Environmental signal of MECHANICAL FORCE that regulates stem cell differentiation !!
- Genes involved in “degree of empathy,” — Empathy Quotient (EQ) is very much a multifactorial trait
- Single-Cell RNA-Seq of Mouse Dopaminergic Neurons Informs Candidate Gene Selection for Sporadic Parkinson Disease
Recent Comments
Archives
- March 2018
- February 2018
- January 2018
- December 2017
- November 2017
- October 2017
- September 2017
- August 2017
- July 2017
- June 2017
- May 2017
- April 2017
- March 2017
- February 2017
- January 2017
- December 2016
- November 2016
- October 2016
- September 2016
- August 2016
- July 2016
- June 2016
- May 2016
- April 2016
- March 2016
- February 2016
- January 2016
- September 2006
- September 1995
- January 1995
- September 1994
- January 1994
- March 1664
Categories
Meta
Monthly Archives: October 2016
Environmental vs endogenous causes of DNA damage, mutation load, in skin fibroblasts
Accumulation of somatic changes, due to environmental and endogenous lesions, in the human genome is associated with aging and cancer. Understanding the impacts of these processes on mutagenesis is fundamental to understanding the etiology, and improving prognosis and prevention of … Continue reading
Posted in Center for Environmental Genetics
Comments Off on Environmental vs endogenous causes of DNA damage, mutation load, in skin fibroblasts
Genetic admixture between two hominid species !!!
Some species, such as giraffe or bottlenose dolphin, are immediately recognizable and might seem absolute, whereas other species, such as bonobo and chimpanzee, seem very closely related. In fact, Darwin in his 1859 book wrote about “strongly-marked varieties” as contrasted … Continue reading
Posted in Center for Environmental Genetics
Comments Off on Genetic admixture between two hominid species !!!
GWAS: Birth weight (BW) associated with future risk of adult metabolic diseases including type-2 diabetes (T2D) and cardiovascular disease
Here is an intriguing ‘gene-environment interactions’ example in which “genes” are those involved in adult-onset type-2 diabetes (T2D) and cardiovascular disease, and “environment” is the uterus in which the embryo/fetus can be affected by maternal diet and stressors, and the … Continue reading
Posted in Center for Environmental Genetics
Comments Off on GWAS: Birth weight (BW) associated with future risk of adult metabolic diseases including type-2 diabetes (T2D) and cardiovascular disease
de novo assembly and phasing of one Korean’s diploid genome
Advances in genome assembly and phasing provide an opportunity to investigate the diploid architecture (i.e. taking into account that each human has pairs of chromosomes––with one allele for each gene on each of the two chromosomes in that pair) of … Continue reading
Posted in Center for Environmental Genetics
Comments Off on de novo assembly and phasing of one Korean’s diploid genome
Genomes of individuals from geograpghically diverse human populations provide insights into the dispersal of modern humans across the planet
Whole genome sequencing (WGS) studies in humans––such as the 1000 Genomes Project, which was completed last year––have contributed to a catalog of genetic variation and genomic regions that have allowed humans the ability to adapt (genetically) to diverse environments (diet, … Continue reading
Posted in Center for Environmental Genetics
Comments Off on Genomes of individuals from geograpghically diverse human populations provide insights into the dispersal of modern humans across the planet
Genetic differences in addiction to morphine … in ants, no less …!!!
Here is a GREAT example of “evolutionary conservation” of genetic pathways in the central nervous system (CNS) between the Order Hymenoptera (including ants) and Primata (primates, including humans). Ants are eusocial insects of the family Formicidae and––along with the related wasps and bees––belong to the order Hymenoptera. Ants evolved from wasp-like ancestors … Continue reading
Posted in Center for Environmental Genetics, Pharmacogenetics
Comments Off on Genetic differences in addiction to morphine … in ants, no less …!!!
Human papilloma virus (HPV) variants were exchanged during admixture of Neaderthal-Denisovians and Homo sapiens sapiens
Every human suffers through life with a number of papillomaviruses (PVs) infections, most of them asymptomatic. One notable exception is persistent infection by Human Papillomavirus-16 (HPV16), the most oncogenic infectious agent for humans and responsible for most infection-driven anogenital cancers. … Continue reading
Posted in Center for Environmental Genetics
Comments Off on Human papilloma virus (HPV) variants were exchanged during admixture of Neaderthal-Denisovians and Homo sapiens sapiens
Evolution of cancer occurs in bursts(?) of evolution or gradual(?) evolution …..
Aneuploidy (abnormal numbers of chromosomes, transposition of segments, and duplicated chromosomes, even in cells adjacent to one another) is a hallmark of many different types of cancer. However, knowledge of how these complex genomic rearrangements evolve during tumorigenesis is still … Continue reading
Posted in Center for Environmental Genetics
Comments Off on Evolution of cancer occurs in bursts(?) of evolution or gradual(?) evolution …..
Transgenerational inheritance” models, mechanisms of non-DNA-sequence based inheritance
Heritability was traditionally thought to be a characteristic feature of the genetic material of an organism—notably, its DNA sequence. During the past several decades, however, it has become clear that inheritance that is independent of DNA sequence exists in the … Continue reading
Posted in Center for Environmental Genetics
Comments Off on Transgenerational inheritance” models, mechanisms of non-DNA-sequence based inheritance
An Independent Review of the Carcinogenic Potential of Glyphosate
Glyphosate [N-(phosphono-methyl)glycine] is a broad-spectrum organophosphorus systemic herbicide and crop desiccant. More specifically, it is a phosphonate––used to kill weeds, especially annual broadleaf weeds and grasses that compete with agricultural crops. An ongoing controversy (more intense in the EU than in the rest of the world) involves whether … Continue reading
Posted in Center for Environmental Genetics
Comments Off on An Independent Review of the Carcinogenic Potential of Glyphosate